Non-Coding RNAs in Endometrial Physiopathology

The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly produces molecules called non-coding RNAs, which are a heterogeneous class of RNAs involved in different steps of gene reg...

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Published inInternational journal of molecular sciences Vol. 19; no. 7; p. 2120
Main Authors Ferlita, Alessandro La, Battaglia, Rosalia, Andronico, Francesca, Caruso, Salvatore, Cianci, Antonio, Purrello, Michele, Pietro, Cinzia Di
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.07.2018
MDPI
Subjects
Antibiotics
Apoptosis
Binding sites
Cancer
Cell cycle
Cell growth
chronic endometritis
Cytokines
Deoxyribonucleic acid
DNA
Embryos
Endometrial cancer
Endometriosis
Endometritis
Endometrium
Gene expression
Gene regulation
Genomes
Growth factors
Human Genome Project
Implantation
In vitro fertilization
Infertility
lncRNAs
miRNA
Proteins
Review
Transfer RNA
Womens health
Italy
lncRNAs
endometrial cancer
endometriosis
miRNA
chronic endometritis
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Summary:The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly produces molecules called non-coding RNAs, which are a heterogeneous class of RNAs involved in different steps of gene regulation. They have been classified, according to their length, into small non-coding RNAs and long non-coding RNAs, or to their function, into housekeeping non-coding RNAs and regulatory non-coding RNAs. Their involvement has been widely demonstrated in all cellular processes, as well as their dysregulation in human pathologies. In this review, we discuss the function of non-coding RNAs in endometrial physiology, analysing their involvement in embryo implantation. Moreover, we explore their role in endometrial pathologies such as endometrial cancer, endometriosis and chronic endometritis.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19072120