Obtainment of the spray-dried extracts of Peperomia pellucida L. (H.B.K.) using different atomization temperatures: physicochemical characterization and technological development for pharmaceutical applications

• Published in: Daru Vol. 29; no. 1; pp. 147 - 158
• Main Authors: da Silva, Rosali Maria Ferreira, Gomes, Thays Cristiane Barbosa Lucena, Campos, Adriana Fernandes, Vilela, Williana Tôrres, Silva, Pollyne Amorim, Sales, Victor de Albuquerque Wanderley, de Medeiros Schver, Giovanna Christinne Rocha, da Silva, Keyla Emmanuelle Ramos, Costa, Salvana Priscylla Manso, de Souza, Fábio Santos, de Freitas, Manolo Cleiton Costa, Arruda, Mara Sílvia Pinheiro, da Silva, Milton Nascimento, Rolim Neto, Pedro José
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 04.04.2021; BioMed Central Ltd; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Cellulose; High performance liquid chromatography; Innovations; Medicinal Chemistry; Particle size; Pharmaceutical Sciences/Technology; Pharmacology/Toxicology; Powders; Quality control; Research Article; Brazil; Scanning electron microscopy; Specific surface area; Spray dryer; HPLC; Peperomia pellucida
• ISSN: 2008-2231; 1560-8115; 2008-2231
• DOI: 10.1007/s40199-021-00393-w

Spray-dried extracts are prepared as powders or granules after solvent removal, which can be obtained in the presence or absence of pharmaceutical adjuvants. This work aimed to optimize the process of obtaining dried extracts of Peperomia pellucida L. (HBK) by spray drying. The characterization of the extract was performed by thermal analysis, specific surface area, particle size and high performance liquid chromatography (HPLC); then, capsules were developed for antimicrobial treatment, evaluating four bench lots by the determination of the angle of repose and time of flow, scanning electron microscopy, porosity and physicochemical quality control. There were no significant differences between the extracts obtained by spray drying at atomization temperatures of 140 °C, 160 °C and 180 °C, which was confirmed by thermal analysis. Specific surface area varied inversely with the mean particle size. Regarding the marker content by HPLC, no significant differences were found between the samples, although the flavonoid fraction was more stable at 160 °C. Bench lots (I to IV) were developed using the diluents Flowlac®, Starch® 1500, microcrystalline cellulose 250 and Cellactose® 80. Based on the results, the bench lot I, containing Flowlac®, was selected. The results of physicochemical quality control demonstrated that the selected formulation meets the pre-established parameters, and proving to be economically viable.