The journey of the organelle: teamwork and regulation in intracellular transport

Specific subsets of biochemical reactions in eukaryotic cells are restricted to individual membrane compartments, or organelles. Cells, therefore, face the monumental task of moving the products of those reactions between individual organelles. Because of the high density of the cytoplasm and the la...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 25; no. 4; pp. 483 - 488
Main Authors Barlan, Kari, Rossow, Molly J, Gelfand, Vladimir I
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2013
Subjects
Animals
Biological Transport
Cytoskeleton - metabolism
Eukaryotic Cells - cytology
Eukaryotic Cells - metabolism
Internal Medicine
Molecular Motor Proteins - metabolism
Organelles - metabolism
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Summary:Specific subsets of biochemical reactions in eukaryotic cells are restricted to individual membrane compartments, or organelles. Cells, therefore, face the monumental task of moving the products of those reactions between individual organelles. Because of the high density of the cytoplasm and the large size of membrane organelles, simple diffusion is grossly insufficient for this task. Proper trafficking between membrane organelles thus relies on cytoskeletal elements and the activity of motor proteins, that act both in transport of membrane compartments and as tethering agents to ensure their proper distribution and to facilitate organelle interactions.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2013.02.018