Effect of Moderate Exercise Training on Peripheral Glucose Effectiveness, Insulin Sensitivity, and Endogenous Glucose Production in Healthy Humans Estimated by a Two-Compartment-Labeled Minimal Model

• Published in: Diabetes (New York, N.Y.) Vol. 53; no. 2; pp. 315 - 320
• Main Authors: NISHIDA, Yuichiro, TOKUYAMA, Kumpei, TANAKA, Hiroaki, NAGASAKA, Shoichiro, HIGAKI, Yasuki, SHIRAI, Yoko, KIYONAGA, Akira, SHINDO, Munehiro, KUSAKA, Ikuyo, NAKAMURA, Tomoatsu, ISHIBASHI, Shun
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.02.2004
• Subjects: Adult; Associated diseases and complications; Biological and medical sciences; Blood Glucose - metabolism; Body Weight; Diabetes; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Exercise; Fatty Acids, Nonesterified - blood; Female; Fitness training programs; Gluconeogenesis; Glucose; Glucose - metabolism; Glucose Tolerance Test; Glucose tolerance tests; Health aspects; Humans; Insulin; Insulin - pharmacology; Lactates - metabolism; Male; Medical sciences; Models, Biological; Physical fitness; Physical Fitness - physiology; Reference Values; Veins & arteries; Workloads; Japan; Endocrinopathy; Physical exercise; Human; Pancreatic hormone; Sensitivity; Diabetes mellitus; Models; Glucose; Insulin
• ISSN: 0012-1797; 1939-327X
• DOI: 10.2337/diabetes.53.2.315

Effect of Moderate Exercise Training on Peripheral Glucose Effectiveness, Insulin Sensitivity, and Endogenous Glucose Production in Healthy Humans Estimated by a Two-Compartment-Labeled Minimal Model Yuichiro Nishida 1 , Kumpei Tokuyama 2 , Shoichiro Nagasaka 3 , Yasuki Higaki 4 , Yoko Shirai 2 , Akira Kiyonaga 1 , Munehiro Shindo 1 , Ikuyo Kusaka 3 , Tomoatsu Nakamura 3 , Shun Ishibashi 3 and Hiroaki Tanaka 1 1 Laboratory of Exercise Physiology, Faculty of Health and Sports Science, Fukuoka University, Fukuoka, Japan 2 Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan 3 Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan 4 Department of Preventive Medicine, Saga Medical School, Saga, Japan Address correspondence and reprint requests to Hiroaki Tanaka, PhD, Laboratory of Exercise Physiology, Faculty of Health and Sports Science, Fukuoka University, 8-19-1 Nanakuma Jonan-Ku, Fukuoka 814-0180, Japan. E-mail: htanaka{at}fukuoka-u.ac.jp Abstract For examining the effects of moderate exercise training on peripheral glucose effectiveness ( S g 2 *), insulin sensitivity ( S i 2 *), and endogenous glucose production (EGP), seven men and one woman (24.8 ± 1.8 years) participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/week for 12 weeks. Stable-labeled frequently sampled intravenous glucose tolerance tests were performed before and 16 h and 1 week after the last training session. S g 2 * (pre 0.71 ± 0.03 × 10 −2 , 16 h 0.85 ± 0.02 × 10 −2 dl · kg −1 · min −1 ) and S i 2 * (pre 12.6 ± 2.6 × 10 −4 , 16 h 19.7 ± 3.3 × 10 −4 dl · kg −1 · min −1 · [μU/ml] −1 ), analyzed using the two-compartment minimal model, were significantly elevated 16 h after the last training session. The elevated S g 2 * remained higher despite the cessation of exercise training for 1 week (1.00 ± 0.03 × 10 −2 dl · kg −1 · min −1 ). EGP was suppressed within 20 min after glucose bolus, and the suppression of EGP was followed by their overshoot. The time course of EGP during the intravenous glucose tolerance test remained similar after the training period. In conclusion, moderate exercise training at lactate threshold improves not only peripheral insulin sensitivity but also peripheral glucose effectiveness with no change in the effect of glucose and/or insulin to suppress EGP in healthy humans. EGP, endogenous glucose production FSIGTT, frequently sampled intravenous glucose tolerance test PCR, plasma clearance rate Footnotes Y.N. is currently affiliated with the Molecular Endocrinology and Oncology Research Center, Laval University Medical Center (CHUL), St. Foy, Quebec, Canada. Accepted October 27, 2003. Received May 3, 2003. DIABETES