Inhibition of hepatic damage and liver fibrosis by brain natriuretic peptide

• Published in: FEBS letters Vol. 583; no. 12; pp. 2067 - 2070
• Main Authors: Sonoyama, Takuhiro, Tamura, Naohisa, Miyashita, Kazutoshi, Park, Kwijun, Oyamada, Naofumi, Taura, Daisuke, Inuzuka, Megumi, Fukunaga, Yasutomo, Sone, Masakatsu, Nakao, Kazuwa
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 18.06.2009
• Subjects: Animals; ANP; atrial natriuretic peptide; BNP; Brain natriuretic peptide; C-type natriuretic peptide; Carbon tetrachloride; Carbon Tetrachloride - toxicity; CCl4; CNP; Col1a1; Collagen Type I - genetics; CYP2E1; cytochrome P450 2E1; dimethylnitrosamine; DMN; guanylyl cyclase; Guanylyl cyclase-A; Hepatic stellate cell; hepatic stellate cell(s) NP, natriuretic peptide; Hepatic Stellate Cells - pathology; Hepatic Stellate Cells - physiology; HSC(s); Liver - pathology; Liver - physiopathology; Liver Cirrhosis, Experimental - chemically induced; Liver Cirrhosis, Experimental - genetics; Liver Cirrhosis, Experimental - pathology; Liver Cirrhosis, Experimental - prevention & control; Liver fibrosis; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NASH; Natriuretic Peptide, Brain - genetics; Natriuretic Peptide, Brain - physiology; non-alcoholic steatohepatitis; reactive oxygen species; RNA, Messenger - genetics; RNA, Messenger - metabolism; ROS; SMA; smooth muscle actin; TGF; transforming growth factor; Transforming Growth Factor beta1 - genetics; transgenic; type I procollagen α1 chain; wild-type; Brain natriuretic peptide; Col1a1; ANP; CNP; DMN; BNP; SMA; Carbon tetrachloride; HSC(s); Liver fibrosis; NASH; Guanylyl cyclase-A; CCl 4; TGF; Tg; ROS; CYP2E1; Hepatic stellate cell; GC; WT
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/j.febslet.2009.05.025

Anti-fibrotic and organ protective effects of brain natriuretic peptide (BNP) have been reported. In this study, effects of BNP on liver fibrosis were examined in the carbon tetrachloride (CCl 4)-induced liver fibrosis model using BNP-transgenic (Tg) and wild-type (WT) mice. Twice-a-week intraperitoneal injections of CCl 4 for 8 weeks resulted in massive liver fibrosis, augmented transforming growth factor (TGF)-β 1 and type I procollagen α 1 chain (Col1a1) mRNA expression, and the hepatic stellate cell (HSC) activation in WT mice, all of which were significantly suppressed in Tg mice. These observations indicate that BNP inhibits liver fibrosis by attenuating the activation of HSCs.