The CTD role in cotranscriptional RNA processing and surveillance

In higher eukaryotes, the production of mature messenger RNA that exits the nucleus to be translated into protein requires precise and extensive processing of the nascent transcript. The processing steps include 5′-end capping, splicing, and 3′-end formation. Pre-mRNA processing is coupled to transc...

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Bibliographic Details
Published inFEBS letters Vol. 582; no. 14; pp. 1971 - 1976
Main Authors de Almeida, Sérgio F., Carmo-Fonseca, Maria
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 18.06.2008
Subjects
7-methyl guanosine
Carboxyl-terminal domain of the largest subunit of RNA Polymerase II
CTD
Exons
Humans
m7G
Protein Structure, Tertiary
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
pyrimidine
RNA polymerase II
RNA Splicing
RNA surveillance
RNA, Messenger - metabolism
splice site
Spliceosomes - metabolism
Splicing
Transcription
Transcription, Genetic
U snRNP
Uridine-rich small nuclear ribonucleoprotein particle
ss
m 7G
CTD
RNA surveillance
Splicing
Transcription
Py
U snRNP
RNA polymerase II
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Summary:In higher eukaryotes, the production of mature messenger RNA that exits the nucleus to be translated into protein requires precise and extensive processing of the nascent transcript. The processing steps include 5′-end capping, splicing, and 3′-end formation. Pre-mRNA processing is coupled to transcription by mechanisms that are not well understood but involve the carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II. This review focuses on recent findings that provide novel insight into the role of the CTD in promoting RNA processing and surveillance.
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ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2008.04.019