Childhood meningitis in rural Gambia: 10 years of population-based surveillance

• Published in: PloS one Vol. 17; no. 8; p. e0265299
• Main Authors: Ikumapayi, Usman N, Hill, Philip C, Hossain, Ilias, Olatunji, Yekini, Ndiaye, Malick, Badji, Henry, Manjang, Ahmed, Salaudeen, Rasheed, Ceesay, Lamin, Adegbola, Richard A, Greenwood, Brian M, Mackenzie, Grant A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.08.2022; Public Library of Science (PLoS)
• Subjects: Age; Antibiotics; Antigens; Bacteria; Bacterial infections; Biology and Life Sciences; Cerebrospinal fluid; Child; Children; Coliforms; Diagnosis; Disease; Diseases; Distribution; Fatalities; Gambia - epidemiology; Gram-Negative Bacteria; Hospitals; Humans; Infant; Malaria; Medical research; Medicine and Health Sciences; Meningitis; Meningitis, Bacterial - cerebrospinal fluid; Meningitis, Bacterial - diagnosis; Meningitis, Bacterial - epidemiology; Morbidity; Neisseria meningitidis; Nosocomial infections; Patients; People and Places; Pneumonia; Population; Rural areas; Serotypes; Streptococcus infections; Streptococcus pneumoniae; Surveillance; Vaccines; Vaccines, Conjugate; Gambia; Belgium; Africa
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0265299

The introduction in many countries of conjugate vaccines against Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis has led to significant reductions in acute bacterial meningitis (ABM) in children. However, recent population-based data on ABM in sub-Saharan Africa are limited. Population-based surveillance for meningitis was carried out in a rural area of The Gambia under demographic surveillance from 2008 to 2017, using standardised criteria for referral, diagnosis and investigation. We calculated incidence using population denominators. We diagnosed 1,666 patients with suspected meningitis and collected cerebrospinal fluid (n = 1,121) and/or blood (n = 1,070) from 1,427 (88%) of cases. We identified 169 cases of ABM, 209 cases of suspected non-bacterial meningitis (SNBM) and 1,049 cases of clinically suspected meningitis (CSM). The estimated average annual incidence of ABM was high at 145 per 100,000 population in the <2-month age group, 56 per 100,000 in the 2-23-month age group, but lower at 5 per 100,000 in the 5-14-year age group. The most common causes of ABM were Streptococcus pneumoniae (n = 44), Neisseria meningitidis (n = 42), and Gram-negative coliform bacteria (n = 26). Eighteen of 22 cases caused by pneumococcal serotypes included in PCV13 occurred prior to vaccine introduction and four afterwards. The overall case fatality ratio for ABM was 29% (49/169) and was highest in the <2-month age group 37% (10/27). The case fatality ratio was 8.6% (18/209) for suspected non-bacterial meningitis and 12.8% (134/1049) for clinically suspected meningitis cases. Gambian children continue to experience substantial morbidity and mortality associated with suspected meningitis, especially acute bacterial meningitis. Such severely ill children in sub-Saharan Africa require improved diagnostics and clinical care.