Effect of Standard and High-Fat Diets during Modeling of Streptozotocin-Induced Diabetes in Rats on the Development of Complications

For evaluation of the effect of high-fat diet on the development of diabetic complications, the rats were maintained on standard or high-fat diet. In 3 weeks, diabetes mellitus was modeled by single intraperitoneal injection of streptozotocin. Changes in hematological parameters, physical and bioche...

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Published inBulletin of experimental biology and medicine Vol. 170; no. 6; pp. 737 - 740
Main Authors Shaykhutdinova, E. R., Palikov, V. A., Palikova, Y. A., Borozdina, N. A., Kravchenko, I. N., Sadovnikova, E. S., Pakhomova, I. A., Rudenko, P. A., Kazakov, V. A., Zharmukhamedova, T. Y., Khokhlova, O. N., Dyachenko, I. A.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.04.2021
Springer
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Blood proteins
Cell Biology
Complications and side effects
Diabetes
Diabetes mellitus
Diet
Ethylenediaminetetraacetic acid
High fat diet
Insulin glulisine
Internal Medicine
Laboratory Medicine
Pain perception
Pathology
Streptozocin
Type 2 diabetes
in vivo model
diabetes mellitus
rats
streptozotocin
high-fat diet
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Summary:For evaluation of the effect of high-fat diet on the development of diabetic complications, the rats were maintained on standard or high-fat diet. In 3 weeks, diabetes mellitus was modeled by single intraperitoneal injection of streptozotocin. Changes in hematological parameters, physical and biochemical parameters of the urine, and in the development of thermal allodynia were different after 15-week standard and high-fat diets.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-021-05144-0