Hypersensitivity to Rabbit Antithymocyte Globulin in an Islet Transplant Recipient: A Case Report

• Published in: Transplantation proceedings Vol. 43; no. 9; pp. 3302 - 3306
• Main Authors: Soleimanpour, S.A, Sekiguchi, D.R, LaRosa, D.F, Luning Prak, E.T, Naji, A, Rickels, M.R
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier Inc 01.11.2011; Elsevier
• Subjects: Adult; Animals; Antilymphocyte Serum - pharmacology; Biological and medical sciences; Blood Sedimentation; C-Reactive Protein - metabolism; Diabetes Mellitus, Type 1 - therapy; Erythema - diagnosis; Erythema - etiology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Glucocorticoids - metabolism; Humans; Hypersensitivity, Immediate - diagnosis; Hypersensitivity, Immediate - etiology; Islets of Langerhans Transplantation - methods; Medical sciences; Methylprednisolone - pharmacology; Rabbits; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Time Factors; Tissue, organ and graft immunology; Human; Hypersensitivity; Langerhans islet; Homograft; Rabbit; Transplantation; Lagomorpha; Homotransplantation; Case study; Medicine; Vertebrata; Mammalia; Treatment; Surgery; Animal; Immunotherapy; Graft; Antithymocyte globulin; Endocrine pancreas
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2011.10.004

Abstract Objective The aim was to describe a case of hypersensitivity to rabbit antithymocyte globulin (rATG) occurring in the context of islet transplantation. Methods A 36-year-old woman with type 1 diabetes was admitted for islet transplantation. rATG was administered the first day (1.5 mg/kg) with methylprednisolone (2 mg/kg), and on the second day (1.5 mg/kg) without glucocorticoid to avoid potential toxicity to the anticipated islet transplant. Results At the end of the rATG infusion on the second day she developed hives over her face, chest, and back and tender erythema at her intravenous site (Arthus reaction). Islet transplantation was not performed. She reported exposure to a pet rabbit for 2 years in childhood. Overnight, fever developed and the rash evolved into an erythematous morbilliform eruption affecting the torso. Serum high-sensitivity C-reactive protein (hsCRP) and the erythrocyte sedimentation rate (ESR) were elevated; serum complements C3 and C4 were normal. She received prednisone (50 mg) with subsequent resolution of the rash. Nine days after her initial reaction, she developed a recurrence of the rash and fever with arthralgias; levels of C3 and C4 had fallen. Methylprednisolone (125 mg, twice) was required for symptom improvement, and was gradually tapered as prednisone over the next 4 weeks with resolution of the complement, ESR, and hsCRP abnormalities. Five months after the initial attempt at islet transplantation, she returned to receive 7,879 IE/kg via portal vein infusion under basiliximab, etanercept, tacrolimus, and sirolimus immunosuppression and has required no to low-dose (0.1 U/kg/d) insulin to maintain near-normal glycemic control for > 12 months after transplantation. Conclusions Our patient's initial hypersensitivity reaction to rATG was followed by immune-complex type 3 hypersensitivity (serum sickness) requiring high-dose glucocorticoids. Canceling the initial islet infusion proved to be wise, and the patient subsequently did well with islet transplantation under an alternative induction agent.