Inhaled Zanamivir for the Prevention of Influenza in Families

Influenzaviruses are frequently transmitted within households. In some epidemics, up to 50 percent of households have one or more members who become infected. The average secondary attack rates among family members is 25 percent, 1 although family composition, the circulating viral strain, and the p...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 343; no. 18; pp. 1282 - 1289
Main Authors Hayden, Frederick G, Gubareva, Larisa V, Monto, Arnold S, Klein, Thomas C, Elliott, Michael J, Hammond, Janet M, Sharp, Stephen J, Ossi, Michael J
Format Journal Article
LanguageEnglish
Published Boston, MA Massachusetts Medical Society 02.11.2000
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Drug dosages
Drug resistance
Households
Influenza virus
Medical sciences
Pharmacology. Drug treatments
zanamivir
United Kingdom > UK
Human
Chemoprophylaxis
Contagion
Inhalation
Result
Zanamivir
Infection
Chemotherapy
Treatment
Viral disease
Double blind study
Family environment
Antiviral
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Summary:Influenzaviruses are frequently transmitted within households. In some epidemics, up to 50 percent of households have one or more members who become infected. The average secondary attack rates among family members is 25 percent, 1 although family composition, the circulating viral strain, and the presence or absence of exposure outside the household 2 influence the likelihood of secondary cases. Amantadine and rimantadine selectively inhibit the ion-channel function of the M2 protein of influenza A viruses. 3 These drugs have been used for postexposure prophylaxis in households, with reductions in influenza among family members (household contacts) of the index patient ranging from 3 to . . .
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM200011023431801