Sirolimus Release from Biodegradable Polymers for Coronary Stent Application: A Review

Drug-eluting stents (DESs) are commonly used for the treatment of coronary artery disease. The evolution of the drug-eluting layer on the surface of the metal stent plays an important role in DES functionality. Here, the use of biodegradable polymers has emerged as an attractive strategy because it...

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Published inPharmaceutics Vol. 14; no. 3; p. 492
Main Authors Xu, Wei, Sasaki, Makoto, Niidome, Takuro
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 24.02.2022
MDPI
Subjects
Acids
Biocompatibility
biodegradable polymer
Cell growth
Clinical trials
Cobalt
drug release
drug-eluting stent
FDA approval
Life sciences
Mechanical properties
Molecular weight
Polymerization
Polymers
Review
sirolimus
Stainless steel
Stents
Thrombosis
Chicago Illinois
United States > US
China
India
drug-eluting stent
drug release
biodegradable polymer
sirolimus
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Summary:Drug-eluting stents (DESs) are commonly used for the treatment of coronary artery disease. The evolution of the drug-eluting layer on the surface of the metal stent plays an important role in DES functionality. Here, the use of biodegradable polymers has emerged as an attractive strategy because it minimizes the occurrence of late thrombosis after stent implantation. Furthermore, understanding the drug-release behavior of DESs is also important for improving the safety and efficacy of stent treatments. Drug release from biodegradable polymers has attracted extensive research attention because biodegradable polymers with different properties show different drug-release behaviors. Molecular weight, composition, glass transition temperature, crystallinity, and the degradation rate are important properties affecting the behavior of polymers. Sirolimus is a conventional anti-proliferation drug and is the most widely used drug in DESs. Sirolimus-release behavior affects endothelialization and thrombosis formation after DES implantation. In this review, we focus on sirolimus release from biodegradable polymers, including synthetic and natural polymers widely used in the medical field. We hope this review will provide valuable up-to-date information on this subject and contribute to the further development of safe and efficient DESs.
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14030492