A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient

• Published in: Mycopathologia (1975) Vol. 183; no. 3; pp. 559 - 564
• Main Authors: Mohd Tap, Ratna, Lim, Teck Choon, Kamarudin, Nur Amalina, Ginsapu, Stephanie Jane, Abd Razak, Mohd Fuat, Ahmad, Norazah, Amran, Fairuz
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.06.2018; Springer; Springer Nature B.V
• Subjects: Agar; Amphotericin B; Antifungal agents; Antiparasitic agents; Biomedical and Life Sciences; Candida auris; Candida tropicalis; Candidemia; Caspofungin; Disease susceptibility; Eukaryotic Microbiology; Fluconazole; Fungal infections; Fungicides; Infection; Isolation media; Itraconazole; Life Sciences; Medical Microbiology; Medical research; Microbial Ecology; Microbiology; Neutropenia; Plant Sciences; rRNA; Short Communication; Test procedures; Voriconazole; Mixed candidemia; Multidrug resistant; Candida auris
• ISSN: 0301-486X; 1573-0832
• DOI: 10.1007/s11046-018-0244-y

We report a fatal case of Candida auris that was involved in mixed candidemia with Candida tropicalis , isolated from the blood of a neutropenic patient. Identification of both isolates was confirmed by amplification and sequencing of internal transcribed spacer and D1/D2 domain of large subunit in rRNA gene. Antifungal susceptibility test by E-test method revealed that C. auris was resistant to amphotericin B, anidulafungin, caspofungin, fluconazole, itraconazole and voriconazole. On the other hand, C. tropicalis was sensitive to all antifungal tested. The use of chromogenic agar as isolation media is vital in detecting mixed candidemia.