Forecasting carbapenem resistance from antimicrobial consumption surveillance: Lessons learnt from an OXA-48-producing Klebsiella pneumoniae outbreak in a West London renal unit

• Published in: International journal of antimicrobial agents Vol. 46; no. 2; pp. 150 - 156
• Main Authors: Gharbi, M, Moore, L.S.P, Gilchrist, M, Thomas, C.P, Bamford, K, Brannigan, E.T, Holmes, A.H
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2015; Elsevier Science Publishers
• Subjects: Anti-Bacterial Agents - therapeutic use; Antimicrobial resistance; Antimicrobial stewardship; beta-Lactam Resistance; beta-Lactamases - metabolism; Carbapenemase; Disease Outbreaks; Drug Utilization; Epidemiological Monitoring; Forecasting; Healthcare-associated infection; Hospitals; Humans; Incidence; Infectious Disease; Klebsiella Infections - drug therapy; Klebsiella Infections - epidemiology; Klebsiella Infections - microbiology; Klebsiella pneumoniae; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - enzymology; Klebsiella pneumoniae - isolation & purification; London - epidemiology; Meropenem; Models, Statistical; Retrospective Studies; Thienamycins - therapeutic use; Time series analyses; London; Carbapenemase; Time series analyses; Antimicrobial stewardship; Healthcare-associated infection; Antimicrobial resistance
• ISSN: 0924-8579; 1872-7913
• DOI: 10.1016/j.ijantimicag.2015.03.005

Highlights • We forecast the incidence rate of carbapenem resistance using antimicrobial usage data. • We assess the impact of an antimicrobial stewardship intervention. • Meropenem usage was highly correlated with the incidence of OXA-48-producing organisms. • While meropenem usage decreased significantly, amikacin usage increased in the renal unit.