Integrative genomic analysis of ghost cell odontogenic carcinoma

Highlights • First whole genome and transcriptome profiling of ghost cell odontogenic carcinoma. • Mutations were detected in novel and known cancer genes. • Expression profiling shows that GCOC is distinct from previously sequenced cancers. • Therapeutic recommendations were made based on integrati...

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Published inOral oncology Vol. 51; no. 9; pp. e71 - e75
Main Authors Bose, Pinaki, Pleasance, Erin D, Jones, Martin, Shen, Yaoqing, Ch’ng, Carolyn, Reisle, Caralyn, Schein, Jacqueline E, Mungall, Andrew J, Moore, Richard, Ma, Yussanne, Sheffield, Brandon S, Thomson, Thomas, Rasmussen, Steven, Ng, Tony, Yip, Stephen, Lee, Christopher W, Ho, Cheryl, Laskin, Janessa, Marra, Marco A, Jones, Steven J
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.2015
Subjects
Asian Continental Ancestry Group - genetics
Facial Bones - pathology
Genomics - methods
Hematology, Oncology and Palliative Medicine
Humans
Male
Odontogenic Tumors - genetics
Odontogenic Tumors - pathology
Otolaryngology
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Summary:Highlights • First whole genome and transcriptome profiling of ghost cell odontogenic carcinoma. • Mutations were detected in novel and known cancer genes. • Expression profiling shows that GCOC is distinct from previously sequenced cancers. • Therapeutic recommendations were made based on integrative pathway analysis.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
content type line 63
ObjectType-Correspondence-1
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2015.06.013