Consumption of isoflavone-rich soy protein does not alter homocysteine or markers of inflammation in postmenopausal women

• Published in: European journal of clinical nutrition Vol. 62; no. 12; pp. 1419 - 1425
• Main Authors: Greany, K.A, Nettleton, J.A, Wangen, K.E, Thomas, W, Kurzer, M.S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2008; Nature Publishing Group
• Subjects: Adhesion; Aged; Amino acids; Biological and medical sciences; biomarkers; Biomarkers - blood; Blood; C-reactive protein; C-Reactive Protein - metabolism; cardioprotective effect; Cardiovascular disease; Cardiovascular diseases; Cell adhesion; Clinical Nutrition; Consumption; Coronary artery disease; Coronary Disease - blood; Coronary Disease - epidemiology; Coronary Disease - prevention & control; Cross-Over Studies; Diet; E-selectin; E-Selectin - blood; Enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - methods; Epidemiology; Fasting; Feeding. Feeding behavior; Female; Folic acid; Food and nutrition; Fundamental and applied biological sciences. Psychology; Health risks; Heart diseases; Homocysteine; Homocysteine - blood; Humans; Inflammation; Inflammation - blood; Inflammation - epidemiology; Inflammation - prevention & control; Intercellular adhesion molecule 1; Intercellular Adhesion Molecule-1 - blood; Internal Medicine; Isoflavones; Isoflavones - administration & dosage; Lipids; Medical sciences; Medicine; Medicine & Public Health; menopause; Metabolic Diseases; Methionine; Middle Aged; Milk; Milk Proteins - administration & dosage; nutrient intake; Nutrient interactions; Nutrition; nutrition physiology; original-article; Post-menopause; Postmenopausal women; Postmenopause - blood; Properties; Proteins; Public Health; Risk factors; Soy products; Soy protein; Soybean products; Soybean Proteins - administration & dosage; Vascular Cell Adhesion Molecule-1 - blood; Vertebrates: anatomy and physiology, studies on body, several organs or systems; women; Womens health; United Kingdom; homocysteine; isoflavone; postmenopausal women; soy; inflammation; Consumption; Human; Isoflavone; Thiol; Metabolic diseases; Inflammation; Marker; Soybean; Sulfur containing aminoacid; Soy protein; Homocystein; Postmenopause; Female; Woman
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/sj.ejcn.1602885

Background/Objective: To investigate the effect of soy protein containing isoflavones on homocysteine (Hcy), C-reactive protein (CRP), soluble E-selectin (sE-selectin), soluble vascular adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1). Subject/Methods: In a randomized crossover design, 34 postmenopausal women consumed soy protein isolate (265 g protein containing 44 +/- 8 mg isoflavones per day) or milk protein isolate (26 +/- 5 g protein per day) for 6 weeks each. Fasting blood samples were collected at the end of each diet period and end points analyzed by enzyme-linked immunosorbent assay. Results: Concentrations of Hcy, CRP, sE-selectin, sVCAM-1 and sICAM-1 were not different between soy and milk diet treatments. Results did not differ by equol production status or by baseline lipid concentration. Adjustment for intake of folate and methionine did not alter the Hcy results. Conclusions: These data suggest that decreasing vascular inflammation and Hcy concentration are not likely mechanisms by which soy consumption reduces coronary heart disease risk.