Variants in HAVCR1 Gene Region Contribute to Hepatitis C Persistence in African Americans

To confirm previously identified polymorphisms in HAVCR1 that were associated with persistent hepatitis C virus (HCV) infection in individuals of African and of European descent, we studied 165 subjects of African descent and 635 subjects of European descent. Because the association was only confirm...

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Published inThe Journal of infectious diseases Vol. 209; no. 3; pp. 355 - 359
Main Authors Wojcik, Genevieve, Latanich, Rachel, Mosbruger, Tim, Astemborski, Jacquie, Kirk, Gregory D., Mehta, Shruti H., Goedert, James J., Kim, Arthur Y., Seaberg, Eric C., Busch, Michael, Thomas, David L., Duggal, Priya, Thio, Chloe L.
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 01.02.2014
Subjects
African Americans
Alleles
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genetic Predisposition to Disease
Genomics
Genotypes
Grants
Haplotypes
Hepacivirus
Hepatitis A Virus Cellular Receptor 1
Hepatitis C
Hepatitis C virus
Hepatitis C, Chronic - genetics
Human genetics
Human viral diseases
Humans
Infections
Infectious diseases
Major and Brief Reports
Male
Medical genetics
Medical sciences
Membrane Glycoproteins - genetics
Microbiology
Polymorphism, Genetic
Receptors, Virus - genetics
Viral diseases
Viral hepatitis
VIRUSES
hepatitis C virus
human genetics
Infection
Digestive diseases
Hepatic disease
Gene
Viral disease
Viral hepatitis C
Tim 1
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Summary:To confirm previously identified polymorphisms in HAVCR1 that were associated with persistent hepatitis C virus (HCV) infection in individuals of African and of European descent, we studied 165 subjects of African descent and 635 subjects of European descent. Because the association was only confirmed in subjects of African descent (rs6880859; odds ratio, 2.42; P = .01), we then used 379 subjects of African descent (142 with spontaneous HCV clearance) to fine-map HAVCR1. rs111511318 was strongly associated with HCV persistence after adjusting for IL28B and HLA (adjusted P = 8.8 × 10⁻⁴), as was one 81-kb haplotype (adjusted P = .0006). The HAVCR1 genomic region is an independent genetic determinant of HCV persistence in individuals of African descent.
Bibliography:ObjectType-Article-1
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Present affiliation: University of Utah, Department of Oncological Sciences, Salt Lake City.
ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1093/infdis/jit444