VE-cadherin: at the front, center, and sides of endothelial cell organization and function

Endothelial cells form cell–cell adhesive structures, called adherens and tight junctions, which maintain tissue integrity, but must be dynamic for leukocyte transmigration during the inflammatory response and cellular remodeling during angiogenesis. This review will focus on Vascular Endothelial (V...

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Published inCurrent opinion in cell biology Vol. 22; no. 5; pp. 651 - 658
Main Authors Harris, Elizabeth S, Nelson, W James
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2010
Subjects
Animals
Antigens, CD - metabolism
Cadherins - metabolism
Cell-Matrix Junctions
Endothelial Cells
Humans
Internal Medicine
Neovascularization, Physiologic
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Summary:Endothelial cells form cell–cell adhesive structures, called adherens and tight junctions, which maintain tissue integrity, but must be dynamic for leukocyte transmigration during the inflammatory response and cellular remodeling during angiogenesis. This review will focus on Vascular Endothelial (VE)-cadherin, an endothelial-specific cell–cell adhesion protein of the adherens junction complex. VE-cadherin plays a key role in endothelial barrier function and angiogenesis, and consequently VE-cadherin availability and function are tightly regulated. VE-cadherin also participates directly and indirectly in intracellular signaling pathways that control cell dynamics and cell cycle progression. Here we highlight recent work that has advanced our understanding of multiple regulatory and signaling mechanisms that converge on VE-cadherin and have consequences for endothelial barrier function and angiogenic remodeling.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2010.07.006