Diagnosis and Treatment of Growth Hormone Deficiency: A Position Statement from Korean Endocrine Society and Korean Society of Pediatric Endocrinology

• Published in: Endocrinology and Metabolism Vol. 35; no. 2; pp. 272 - 287
• Main Authors: Kim, Jung Hee, Chae, Hyun Wook, Chin, Sang Ouk, Ku, Cheol Ryong, Park, Kyeong Hye, Lim, Dong Jun, Kim, Kwang Joon, Lim, Jung Soo, Kim, Gyuri, Choi, Yun Mi, Ahn, Seong Hee, Jeon, Min Ji, Hwangbo, Yul, Lee, Ju Hee, Kim, Bu Kyung, Choi, Yong Jun, Lee, Kyung Ae, Moon, Seong-Su, Ahn, Hwa Young, Choi, Hoon Sung, Hong, Sang Mo, Shin, Dong Yeob, Seo, Ji A, Kim, Se Hwa, Oh, Seungjoon, Yu, Sung Hoon, Kim, Byung Joon, Shin, Choong Ho, Kim, Sung-Woon, Kim, Chong Hwa, Lee, Eun Jig
• Format: Journal Article
• Language: English
• Published: Korean Endocrine Society 01.06.2020; 대한내분비학회
• Subjects: Child; Diseases of the endocrine glands. Clinical endocrinology; dwarfism; Growth Disorders; Growth hormone; Hormone Replacement Therapy; Human Growth Hormone; Humans; Hypopituitarism; pituitary; Practice Guidelines as Topic; Prognosis; RC648-665; Societies, Scientific; Special; Special Article; 내과학
• ISSN: 2093-596X; 2093-5978; 2093-5978
• DOI: 10.3803/enm.2020.35.2.272

Growth hormone (GH) deficiency is caused by congenital or acquired causes and occurs in childhood or adulthood. GH replacement therapy brings benefits to body composition, exercise capacity, skeletal health, cardiovascular outcomes, and quality of life. Before initiating GH replacement, GH deficiency should be confirmed through proper stimulation tests, and in cases with proven genetic causes or structural lesions, repeated GH stimulation testing is not necessary. The dosing regimen of GH replacement therapy should be individualized, with the goal of minimizing side effects and maximizing clinical improvements. The Korean Endocrine Society and the Korean Society of Pediatric Endocrinology have developed a position statement on the diagnosis and treatment of GH deficiency. This position statement is based on a systematic review of evidence and expert opinions.Growth hormone (GH) deficiency is caused by congenital or acquired causes and occurs in childhood or adulthood. GH replacement therapy brings benefits to body composition, exercise capacity, skeletal health, cardiovascular outcomes, and quality of life. Before initiating GH replacement, GH deficiency should be confirmed through proper stimulation tests, and in cases with proven genetic causes or structural lesions, repeated GH stimulation testing is not necessary. The dosing regimen of GH replacement therapy should be individualized, with the goal of minimizing side effects and maximizing clinical improvements. The Korean Endocrine Society and the Korean Society of Pediatric Endocrinology have developed a position statement on the diagnosis and treatment of GH deficiency. This position statement is based on a systematic review of evidence and expert opinions.