Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers

Altered metabolic patterns in tumor cells not only meet their own growth requirements but also shape an immunosuppressive microenvironment through multiple mechanisms. Noncoding RNAs constitute approximately 60% of the transcriptional output of human cells and have been shown to regulate numerous ce...

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Published inJournal of hematology and oncology Vol. 14; no. 1; pp. 1 - 26
Main Authors Zhang, Yiyin, Mao, Qijiang, Xia, Qiming, Cheng, Jiaxi, Huang, Zhengze, Li, Yirun, Chen, Peng, Yang, Jing, Fan, Xiaoxiao, Liang, Yuelong, Lin, Hui
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 15.10.2021
BioMed Central
BMC
Subjects
Adenosine
Amino acids
Antigens
Apoptosis
B cells
Bioinformatic approach
Cancer
Cytotoxicity
Enzymes
Fatty acids
Genetic transcription
Hematology
Immune microenvironment
Immune response
Immunotherapy
Infiltration
Lymphocytes
Metabolism
Metabolites
Metastases
Microenvironments
miRNA
Noncoding RNAs
Nutrient requirements
Oncology
Physiological aspects
Review
TIMELnc manual
Transcription
Tumor cells
Tumor metabolism
Tumors
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Summary:Altered metabolic patterns in tumor cells not only meet their own growth requirements but also shape an immunosuppressive microenvironment through multiple mechanisms. Noncoding RNAs constitute approximately 60% of the transcriptional output of human cells and have been shown to regulate numerous cellular processes under developmental and pathological conditions. Given their extensive action mechanisms based on motif recognition patterns, noncoding RNAs may serve as hinges bridging metabolic activity and immune responses. Indeed, recent studies have shown that microRNAs, long noncoding RNAs and circRNAs are widely involved in tumor metabolic rewiring, immune cell infiltration and function. Hence, we summarized existing knowledge of the role of noncoding RNAs in the remodeling of tumor metabolism and the immune microenvironment, and notably, we established the TIMELnc manual, which is a free and public manual for researchers to identify pivotal lncRNAs that are simultaneously correlated with tumor metabolism and immune cell infiltration based on a bioinformatic approach. Keywords: Noncoding RNAs, Tumor metabolism, Immune microenvironment, TIMELnc manual, Bioinformatic approach
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ISSN:1756-8722
1756-8722
DOI:10.1186/s13045-021-01179-y