Replay of Neuronal Firing Sequences in Rat Hippocampus During Sleep Following Spatial Experience

• Published in: Science (American Association for the Advancement of Science) Vol. 271; no. 5257; pp. 1870 - 1873
• Main Authors: Skaggs, William E., McNaughton, Bruce L.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 29.03.1996; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Action Potentials; Animals; Behavioral neuroscience; Behavioral psychophysiology; Biological and medical sciences; Cellular biology; Correlation; Datasets; Electrophysiology; Environment; Fundamental and applied biological sciences. Psychology; Hippocampus; Long term potentiation; Long-Term Potentiation - physiology; Male; Memory; Memory - physiology; Motor Activity; Neurons; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Pyramidal cells; Pyramidal Cells - physiology; Rats; Rats, Inbred F344; Rodents; Sleep; Sleep - physiology; Statistical Analysis; Tetrodes; Theta Rhythm; Time Factors; Time windows; Vigilance; Sleep stage; Rat; Exploratory behavior; Rodentia; Central nervous system; Discharge pattern; Electrophysiology; Male; Space perception; Slow wave sleep; Vertebrata; Mammalia; Acquisition process; Animal; Perception; Perceptive learning; Hippocampus; Brain (vertebrata)
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.271.5257.1870

The correlated activity of rat hippocampal pyramidal cells during sleep reflects the activity of those cells during earlier spatial exploration. Now the patterns of activity during sleep have also been found to reflect the order in which the cells fired during spatial exploration. This relation was reliably stronger for sleep after the behavioral session than before it; thus, the activity during sleep reflects changes produced by experience. This memory for temporal order of neuronal firing could be produced by and interaction between the temporal integration properties of long-term potentiation and the phase shifting of spike activity with respect to the hippocampal theta rhythm.