Liver Function Assessment Using Parenchyma-Specific Contrast-Enhanced Ultrasonography

• Published in: Ultrasound in medicine & biology Vol. 42; no. 2; pp. 430 - 437
• Main Authors: Park, Jaehyung, Cho, Jinhan, Kwon, Heejin, Kang, Myongjin, Lee, Sangyun, Roh, Young-hoon, Kim, Kwan Woo, Lee, Sung Wook
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.02.2016
• Subjects: Aged; Aged, 80 and over; Computer Simulation; Contrast Media - pharmacokinetics; Contrast-enhanced ultrasonography; Female; Ferric Compounds - pharmacokinetics; Humans; Image Interpretation, Computer-Assisted - methods; Indocyanine green; Iron - pharmacokinetics; Liver - diagnostic imaging; Liver - metabolism; Liver cirrhosis; Liver Cirrhosis - diagnostic imaging; Liver Cirrhosis - metabolism; Liver function; Liver Function Tests - methods; Male; Metabolic Clearance Rate; Microbubble contrast agent; Middle Aged; Models, Biological; Oxides - pharmacokinetics; Radiology; Reproducibility of Results; Sensitivity and Specificity; Sonazoid; Ultrasonography - methods; Liver function; Microbubble contrast agent; Indocyanine green; Sonazoid; Contrast-enhanced ultrasonography; Liver cirrhosis
• ISSN: 0301-5629; 1879-291X
• DOI: 10.1016/j.ultrasmedbio.2015.08.020

Abstract The aim of this study was to assess hepatic functional reserve by analyzing the hepatic parenchyma enhancement curve of parenchyma-specific contrast-enhanced ultrasonography (CEUS). Fifty-two patients with cirrhosis who underwent CEUS and indocyanine green tests (ICG) because of a focal liver lesion were enrolled. We evaluated the hemodynamic-related parameters of the time-intensity curve and compared these findings with the ICG retention rate at 15 min (ICG R15). The correlation between the time from peak to one half (s) and ICG R15 was statistically significant and was relatively proportional to the ICG R15. A cut-off value of 149 s was determined for the time from peak to one half for abnormal ICG R15 (>14). The sensitivity and specificity were 85.7% and 92.3%, respectively, for the detection of abnormal ICG R15. In conclusion, the time from peak to one half of the time-intensity curve of parenchyma-specific CEUS of the liver can be a useful parameter to predict the hepatic reserve in liver cirrhosis.