Molecular design of the microbial cell surface toward the recovery of metal ions

• Published in: Current opinion in biotechnology Vol. 22; no. 3; pp. 427 - 433
• Main Authors: Kuroda, Kouichi, Ueda, Mitsuyoshi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2011
• Subjects: Adsorption; Biodegradation, Environmental; Biotechnology; breeding; Cell Membrane - chemistry; Cell Membrane - metabolism; engineering; Environmental Pollutants - chemistry; Environmental Pollutants - metabolism; Genetic Engineering; Internal Medicine; Ions - chemistry; Ions - metabolism; Metal ions; metals; Metals - metabolism; Microorganisms; Organisms, Genetically Modified; Peptides; Peptides - chemistry; Peptides - metabolism; pollution; Proteins; Recovery; Strategy; Surface chemistry
• ISSN: 0958-1669; 1879-0429
• DOI: 10.1016/j.copbio.2010.12.006

The genetic engineering of microorganisms to adsorb metal ions is an attractive method to facilitate the environmental cleanup of metal pollution and to enrich the recovery of metal ions such as rare metal ions. For the recovery of metal ions by microorganisms, cell surface design is an effective strategy for the molecular breeding of bioadsorbents as an alternative to intracellular accumulation. The cell surface display of known metal-binding proteins/peptides and the molecular design of novel metal-binding proteins/peptides have been performed using a cell surface engineering approach. The adsorption of specific metal ions is the important challenge for the practical recovery of metal ions. In this paper, we discuss the recent progress in surface-engineered bioadsorbents for the recovery of metal ions.