A Case of a Patient Who Is Diagnosed with Mild Acquired Hemophilia A after Tooth Extraction Died of Acute Subdural Hematoma due to Head Injury

Background. Acquired hemophilia A (AHA) is a rare disorder which results from the presence of autoantibodies against blood coagulation factor VIII. The initial diagnosis is based on the detection of an isolated prolongation of the activated partial thromboplastin time (aPTT) with negative personal a...

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Published inCase reports in dentistry Vol. 2018; no. 2018; pp. 1 - 3
Main Authors Fukushima, Yosuke, Ikami, Eiji, Sato, Tsuyoshi, Kitamura, Tomohisa, Yoda, Tetsuya
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2018
Hindawi
Hindawi Limited
Wiley
Subjects
Autoantibodies
Autoimmunity
Bleeding
Blood clots
Blood coagulation
Blood tests
Brain
Case Report
Case reports
Coagulation factor VIII
Coagulation factors
Dentistry
Dentists
Diagnosis
Dura mater
Factor VIII
Factor VIII deficiency
Family medical history
Head injuries
Health aspects
Hematoma
Hemophilia
Hemorrhage
Hospitals
Laboratories
Lupus
Maxillofacial surgery
Medical diagnosis
Meninges
Patients
Subdural hematoma
Surgery
Teeth
Thromboplastin
Japan
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Summary:Background. Acquired hemophilia A (AHA) is a rare disorder which results from the presence of autoantibodies against blood coagulation factor VIII. The initial diagnosis is based on the detection of an isolated prolongation of the activated partial thromboplastin time (aPTT) with negative personal and family history of bleeding disorder. Definitive diagnosis is the identification of reduced FVIII levels with evidence of FVIII neutralizing activity. Case report. We report a case of a 93-year-old female who was diagnosed as AHA after tooth extraction at her home clinic. Prolongation of aPTT and a reduction in factor VIII activity levels were observed with the presence of factor VIII inhibitor. AHA condition is mild. However, acute subdural hematoma of this patient occurred due to an unexpected accident in our hospital. Hematoma was gradually increased and the patient died 13 days after admission. Discussion. Although AHA is mild, intracranial bleeding is a life-threatening condition. We also should pay attention to the presence of AHA patients when we extract teeth.
Bibliography:Academic Editor: Yuk-Kwan Chen
ISSN:2090-6447
2090-6455
DOI:10.1155/2018/7185263