Cadmium monitoring in saliva and urine as indicator of smoking addiction

• Published in: The Science of the total environment Vol. 408; no. 16; pp. 3125 - 3132
• Main Authors: Talio, María Carolina, Luconi, Marta O., Masi, Adriana N., Fernández, Liliana P.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 15.07.2010; [Amsterdam; New York]: Elsevier Science; Elsevier
• Subjects: Biological; Biological and medical sciences; Cadmium; Cadmium - metabolism; Cadmium - urine; Chemical and industrial products toxicology. Toxic occupational diseases; Extraction; Female; Humans; Linearity; Male; mastication; Medical sciences; metabolism; Metals and various inorganic compounds; Molecular fluorescence; Monitoring; Reproducibility of Results; Saliva; Saliva - metabolism; Salivary cadmium; Sampling; Second hand smoke exposure; smokeless tobacco; Smoker and non-smoker subjects; Smoking; smoking (habit); Smoking - metabolism; Smoking - urine; Spectrometry, Fluorescence; Stability test; Tobacco; Tobacco, tobacco smoking; Toxicology; Urinary cadmium; Urine; variance; Smoker and non-smoker subjects; Molecular fluorescence; Stability test; Salivary cadmium; Second hand smoke exposure; Urinary cadmium; Human; Urine; Cadmium; Biological fluid; Tobacco smoking; Exploration; Transition metal; Heavy metal; Cigarette; Addiction; Smoker; Passive smoking; Saliva; Public health; Quantitative analysis
• ISSN: 0048-9697; 1879-1026; 1879-1026
• DOI: 10.1016/j.scitotenv.2010.03.052

Cadmium is one of the many substances that may be acquired through active and passive smoking of tobacco. Saliva and urine are proposed for cadmium monitoring of non-smokers, second hand smokers, smokers and tobacco chewing appertaining to San Luis citizens without occupational exposition. Biological samples were collected by the same subjects, under strict proceeding instructions of sampling. Physical characteristics of samples were observed and checked with commercial test. Samples were analyzed using an adapted molecular fluorescence methodology with a previous extraction step. Stability of biological samples was daily studied for a period of one month. The method was successfully validated for accuracy, precision, linearity, specificity, and sensitivity. The simplicity and low coefficient of variance confirm the suitability of the method for urinary and salivary cadmium analyses. On the other side, the obtained results are in concordance with previous national epidemiological dates.