Bone marrow angiogenesis in myeloma and its precursor disease: a prospective clinical trial

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Bibliographic Details
Published inLeukemia Vol. 28; no. 2; pp. 413 - 416
Main Authors Bhutani, M, Turkbey, B, Tan, E, Kemp, T J, Pinto, L A, Berg, A R, Korde, N, Minter, A R, Weiss, B M, Mena, E, Lindenberg, L, Aras, O, Purdue, M P, Hofmann, J N, Steinberg, S M, Calvo, K R, Choyke, P L, Maric, I, Kurdziel, K, Landgren, O
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.02.2014
Subjects
Angiogenesis
Biological markers
Biomarkers
Bone marrow
Bone Marrow - pathology
Cancer therapies
Clinical trials
Cloning
DNA methylation
Epigenetics
Gene expression
Health aspects
Humans
Letters to the editor
Leukemia
Magnetic Resonance Imaging
Monoclonal Gammopathy of Undetermined Significance - diagnosis
Monoclonal Gammopathy of Undetermined Significance - pathology
Multiple myeloma
Multiple Myeloma - diagnosis
Multiple Myeloma - pathology
Myelodysplastic syndromes
Myeloma
Neovascularization
Neovascularization, Pathologic
Patient outcomes
United States > US
Sweden
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AUTHOR CONTRIBUTIONS
O Landgren, K Kurdziel and E Tan, designed the study. E Tan coordinated the enrollment of patients and collected clinical data for the patients on this trial. N Korde, AR Minter, BM Weiss, and O Landgren saw the patients in clinic. I Maric and A Berg did the main analysis by immunohistochemistry to define MVD. B Turkbey did the main analysis by DCE-MRI. P Choyke and K Kurdziel reviewed the imaging data. M Purdue and J Hofmann performed preliminary quality control analyses for the serum angiogenesis markers and developed the protocol for measurements in selected patients. T Kemp and L Pinto did the ELISA cytokine analysis. M Bhutani and A Berg compiled clinical, imaging, serum marker, and bone marrow data for statistical analysis. S Steinberg did the statistical analysis. M Bhutani, I Maric and O Landgren wrote the manuscript. All the authors were involved in the interpretation of the results. All authors read, gave comments, and approved the final version of the manuscript. All the authors had full access to the data in the study and take responsibility for the accuracy of the data analysis.
ISSN:0887-6924
1476-5551
DOI:10.1038/leu.2013.268