Synthesis and production of the antitumor polyketide aurovertins and structurally related compounds

• Published in: Applied microbiology and biotechnology Vol. 102; no. 15; pp. 6373 - 6381
• Main Authors: Li, Wei, Ma, Zihui, Chen, Lin, Yin, Wen-Bing
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2018; Springer; Springer Nature B.V
• Subjects: Antibacterial activity; antibacterial properties; Anticancer properties; Antineoplastic agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Aurovertins - chemical synthesis; Aurovertins - chemistry; biochemical pathways; Bioengineering; Biomedical and Life Sciences; Biosynthesis; Biotechnology; Chemical properties; Chemical synthesis; Design engineering; engineering; Fungi; Fungi - genetics; Fungi - metabolism; Industrial Microbiology; Laboratories; Life Sciences; Metabolic engineering; Metabolic pathways; Microbial Genetics and Genomics; Microbiology; Mini-Review; Organic chemistry; Polyketides; Polyketide; Aurovertin; Antitumor activity; Biosynthesis; Natural products

Aurovertins belong to a family of highly reducing polyketides sharing a polyene α-pyrone-type structure. These compounds comprise aurovertin, asteltoxin, avertoxin, citreoviridin, verrucosidin, and their derivatives, which exihibit potent antitumor, antiviral, and antibacterial activities. Until now...