Synthesis and production of the antitumor polyketide aurovertins and structurally related compounds

• Published in: Applied microbiology and biotechnology Vol. 102; no. 15; pp. 6373 - 6381
• Main Authors: Li, Wei, Ma, Zihui, Chen, Lin, Yin, Wen-Bing
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2018; Springer; Springer Nature B.V
• Subjects: Antibacterial activity; antibacterial properties; Anticancer properties; Antineoplastic agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Aurovertins - chemical synthesis; Aurovertins - chemistry; biochemical pathways; Bioengineering; Biomedical and Life Sciences; Biosynthesis; Biotechnology; Chemical properties; Chemical synthesis; Design engineering; engineering; Fungi; Fungi - genetics; Fungi - metabolism; Industrial Microbiology; Laboratories; Life Sciences; Metabolic engineering; Metabolic pathways; Microbial Genetics and Genomics; Microbiology; Mini-Review; Organic chemistry; Polyketides; Polyketide; Aurovertin; Antitumor activity; Biosynthesis; Natural products
• ISSN: 0175-7598; 1432-0614; 1432-0614
• DOI: 10.1007/s00253-018-9123-1

Aurovertins belong to a family of highly reducing polyketides sharing a polyene α-pyrone-type structure. These compounds comprise aurovertin, asteltoxin, avertoxin, citreoviridin, verrucosidin, and their derivatives, which exihibit potent antitumor, antiviral, and antibacterial activities. Until now, over 40 aurovertins and structurally related compounds have been found in the fungal kingdom. Due to the unique structural feature and interesting bioactivities, significant progresses have been achieved for the structural identification, chemical synthesis, and biosynthesis of the mentioned compounds. Understanding of aurovertin biosynthetic mechanism provides a solid basis for engineering the metabolic pathway of those compounds by rational design and realizing their production in the model fungal host.