New prenylxanthones from the deep-sea derived fungus Emericella sp. SCSIO 05240

• Published in: Marine drugs Vol. 12; no. 6; pp. 3190 - 3202
• Main Authors: Fredimoses, Mangaladoss, Zhou, Xuefeng, Lin, Xiuping, Tian, Xinpeng, Ai, Wen, Wang, Junfeng, Liao, Shengrong, Liu, Juan, Yang, Bin, Yang, Xianwen, Liu, Yonghong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.05.2014; MDPI
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Crystallography, X-Ray; deep-sea; Emericella; Emericella - metabolism; fungus; Geologic Sediments - microbiology; Magnetic Resonance Spectroscopy; Marine; prenylxanthone; Xanthones - chemistry; Xanthones - isolation & purification; Xanthones - pharmacology
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md12063190

Four new prenylxanthones, emerixanthones A-D (1-4), together with six known analogues (5-10), were isolated from the culture of the deep-sea sediment derived fungus Emericella sp. SCSIO 05240, which was identified on the basis of morphology and ITS sequence analysis. The newstructures were determined by NMR (1H, 13C NMR, HSQC, HMBC, and 1H-1H COSY), MS, CD, and optical rotation analysis. The absolute configuration of prenylxanthone skeleton was also confirmed by the X-ray crystallographic analysis. Compounds 1and 3 showed weak antibacterial activities, and 4 displayed mild antifungal activities against agricultural pathogens.