A Ball‐Milling‐Enabled Reformatsky Reaction

• Published in: ChemSusChem Vol. 12; no. 12; pp. 2554 - 2557
• Main Authors: Cao, Qun, Stark, Roderick T., Fallis, Ian A., Browne, Duncan L.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 21.06.2019; John Wiley and Sons Inc
• Subjects: ball milling; Comminution; Communication; Communications; mechanochemistry; Morphology; organozinc formation; Rare gases; reformatsky reaction; Substrates; Zinc; organozinc formation; mechanochemistry; ball milling; reformatsky reaction
• ISSN: 1864-5631; 1864-564X
• DOI: 10.1002/cssc.201900886

An operationally simple one‐jar one‐step mechanochemical Reformatsky reaction using in situ generated organozinc intermediates under neat grinding conditions has been developed. Notable features of this reaction protocol are that it requires no solvent, no inert gases, and no pre‐activation of the bulk zinc source. The developed process is demonstrated to have good substrate scope (39–82 % yield) and is effective irrespective of the initial morphology of the zinc source. I Zinc we've got it: An operationally simple one‐jar one‐step mechanochemical Reformatsky reaction using in situ‐generated organozinc intermediates under neat grinding conditions has been developed. This reaction requires no solvent, no inert gases, and no pre‐activation of the bulk zinc source. The process demonstrates good substrate scope (39–82 % yield) and is effective irrespective of the initial morphology of the zinc source.