The Development of a General Strategy for the Synthesis of Tyramine-Based Natural Products by Using Continuous Flow Techniques
A flowing future! A multistep, general flow chemistry protocol has been developed for the preparation of tyramine‐based natural products. The process integrates room‐temperature reactions with high‐temperature Heck coupling reactions, where the heat has been supplied by microwave irradiation. As a p...
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Published in | Chemistry : a European journal Vol. 16; no. 43; pp. 12797 - 12800 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
15.11.2010
WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | A flowing future! A multistep, general flow chemistry protocol has been developed for the preparation of tyramine‐based natural products. The process integrates room‐temperature reactions with high‐temperature Heck coupling reactions, where the heat has been supplied by microwave irradiation. As a proof of concept for ‘scaling out’ to attain larger quantities of the desired products, the four primary tyramine‐based natural products were prepared on a gram scale using this synthetic protocol. |
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Bibliography: | NSERC (Canada) ark:/67375/WNG-5S6B268G-C ORDCF (Ontario) istex:1E54B9BDC8916AF47950B5794C4802D92FF07BCC NIH Center for Chemical Methodologies and Library Development - No. P50 GM069663 ArticleID:CHEM201002102 NIH RePORTER ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0947-6539 1521-3765 |
DOI: | 10.1002/chem.201002102 |