New Designs for Phototherapeutic Transition Metal Complexes

In this Minireview, we highlight recent advances in the design of transition metal complexes for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT), and discuss the challenges and opportunities for the translation of such agents into clinical use. New designs for light‐activated trans...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 59; no. 1; pp. 61 - 73
Main Authors Imberti, Cinzia, Zhang, Pingyu, Huang, Huaiyi, Sadler, Peter J.
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 02.01.2020
John Wiley and Sons Inc
EditionInternational ed. in English
Subjects
anticancer
Chemical compounds
Chemotherapy
Coordination Complexes - chemistry
Coordination compounds
Drugs
Humans
Irradiation
Light irradiation
Metal complexes
Metals - chemistry
Minireview
Minireviews
Oxidation
photoactivated chemotherapy
Photochemicals
Photochemotherapy - methods
Photodynamic therapy
Prodrugs
Radiation
Selectivity
Transition metal compounds
Valence
metal complexes
photoactivated chemotherapy
photodynamic therapy
anticancer
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Summary:In this Minireview, we highlight recent advances in the design of transition metal complexes for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT), and discuss the challenges and opportunities for the translation of such agents into clinical use. New designs for light‐activated transition metal complexes offer photoactivatable prodrugs with novel targeted mechanisms of action. Light irradiation can provide spatial and temporal control of drug activation, increasing selectivity and reducing side‐effects. The photophysical and photochemical properties of transition metal complexes can be controlled by the appropriate choice of the metal, its oxidation state, the number and types of ligands, and the coordination geometry. Light irradiation can provide spatial and temporal control of drug activation, increasing selectivity and reducing side‐effects. This Minireview summarizes new designs for light‐activated transition metal complexes which offer photoactivatable prodrugs with novel targeted mechanisms of action for use in photodynamic therapy (PDT) and photoactivated chemotherapy (PACT).
Bibliography:These authors contributed equally to this work.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201905171