Transition‐Metal‐Catalyzed Selective Functionalization of C(sp3)−H Bonds in Natural Products

• Published in: Angewandte Chemie International Edition Vol. 57; no. 16; pp. 4234 - 4241
• Main Authors: Karimov, Rashad R., Hartwig, John F.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 09.04.2018
• Edition: International ed. in English
• Subjects: amination; Biological Products - chemical synthesis; Biological Products - chemistry; Catalysis; Chemical bonds; C−H bond functionalization; Molecular Conformation; Molecular structure; Natural products; oxidation; regioselectivity; Transition Elements - chemistry; regioselectivity; oxidation; catalysis; amination; C−H bond functionalization
• ISSN: 1433-7851; 1521-3773; 1521-3773
• DOI: 10.1002/anie.201710330

Direct functionalization of natural products is important for studying the structure–activity and structure–property relationships of these molecules. Recent advances in the transition‐metal‐catalyzed functionalization of C(sp3)−H bonds, the most abundant yet inert bonds in natural products, have allowed natural product derivatives to be created selectively. Strategies to achieve such transformation are reviewed. Direct derivatization: Direct functionalization of natural products is important for studying their structure–activity and structure–property relationships. Recent advances in the transition‐metal‐catalyzed functionalization of C(sp3)−H bonds have shown that natural product derivatives can be selectively produced. Strategies for achieving such transformations are discussed.