Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinami...

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Published inAngewandte Chemie International Edition Vol. 58; no. 15; pp. 4948 - 4952
Main Authors Megarity, Clare F., Siritanaratkul, Bhavin, Heath, Rachel S., Wan, Lei, Morello, Giorgio, FitzPatrick, Sarah R., Booth, Rosalind L., Sills, Adam J., Robertson, Alexander W., Warner, Jamie H., Turner, Nicholas J., Armstrong, Fraser A.
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.04.2019
John Wiley and Sons Inc
EditionInternational ed. in English
Subjects
Chloroplasts
cofactor recycling
Cofactors
Communication
Communications
electrocatalysis
Electrode materials
Electrodes
Enzymes
Ferredoxin
ferredoxin NADP+ reductase
Indium tin oxides
Metabolites
Mitochondria
NADP
NADPH-diaphorase
nanoconfinement
Nicotinamide
Nicotinamide adenine dinucleotide
Organic chemistry
Pores
Reductase
Stroma
Tin
ferredoxin NADP+ reductase
nanoconfinement
electrocatalysis
cofactor recycling
nicotinamide
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Summary:In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP+ are cycled rapidly between ferredoxin–NADP+ reductase and a second enzyme—the pairs being juxtaposed within the 5–100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme‐catalysed reactions. In close quarters: Nicotinamide adenine dinucleotide phosphate (NADPH) and NADP+ are cycled rapidly between ferredoxin–NADP+ reductase (FNR) and a dehydrogenase enzyme (E2) within the 5–100 nm pores of an indium tin oxide electrode. The electrode mimics the nanoconfinement strategies of natural systems, such as the chloroplast stroma or mitochondria in living cells.
Bibliography:These authors contributed equally to this work.
ObjectType-Article-1
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201814370