循环肿瘤细胞研究进展：从计数到表型的转变
尽管循环肿瘤细胞（CTCs）的发现已有较长时间，但自第一台用于检测CTCs的Cellsearch平台上市之后，CTCs才开始得到重视并深入研究。目前，CTCs已经从单纯的计数走向分子分型时代，随着测序技术的发展和液体活检需求的提高，利用CTCs行单细胞测序已成为可能。如何充分利用CTCs揭示肿瘤的发生与发展，判断患者的生存和预后已经成为关注的热点。...
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| Published in | 中华肿瘤杂志 Vol. 38; no. 12; pp. 881 - 885 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
军事医学科学院附属医院乳腺肿瘤科, 北京,100071
2016
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| Subjects | |
| Online Access | Get full text |
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| Abstract | 尽管循环肿瘤细胞（CTCs）的发现已有较长时间，但自第一台用于检测CTCs的Cellsearch平台上市之后，CTCs才开始得到重视并深入研究。目前，CTCs已经从单纯的计数走向分子分型时代，随着测序技术的发展和液体活检需求的提高，利用CTCs行单细胞测序已成为可能。如何充分利用CTCs揭示肿瘤的发生与发展，判断患者的生存和预后已经成为关注的热点。 |
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| AbstractList | 尽管循环肿瘤细胞（ CTCs ）的发现已有较长时间，但自第一台用于检测 CTCs 的Cellsearch平台上市之后，CTCs才开始得到重视并深入研究。目前，CTCs已经从单纯的计数走向分子分型时代，随着测序技术的发展和液体活检需求的提高，利用CTCs行单细胞测序已成为可能。如何充分利用CTCs揭示肿瘤的发生与发展，判断患者的生存和预后已经成为关注的热点。 尽管循环肿瘤细胞（CTCs）的发现已有较长时间，但自第一台用于检测CTCs的Cellsearch平台上市之后，CTCs才开始得到重视并深入研究。目前，CTCs已经从单纯的计数走向分子分型时代，随着测序技术的发展和液体活检需求的提高，利用CTCs行单细胞测序已成为可能。如何充分利用CTCs揭示肿瘤的发生与发展，判断患者的生存和预后已经成为关注的热点。 |
| Abstract_FL | Although circulating tumor cells(CTCs) have long been identified,it was not until the approval of CellSearch? system that CTCs are current lyunder in?depth investigation.The CTCs technology has advanced from simple cell counting into era of molecular subtyping. The development of sequencing technologies and liquid biopsy has made it possible to sequence single cell genomes. In the recent years, how to take advantage of CTCs as a useful tool to clarify the mechanisms of carcinogenesis and cancer development and to predict the patient survival have become a hot issue. |
| Author | 李健斌 江泽飞 |
| AuthorAffiliation | 军事医学科学院附属医院乳腺肿瘤科,北京100071 |
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| Author_FL | Li Jianbin Jiang Zefei |
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| Author_xml | – sequence: 1 fullname: 李健斌 江泽飞 |
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| DocumentTitleAlternate | Research progress of circulating tumor cells ： the way from counting to subtyping |
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| Keywords | Subject words] Circulating tumor cells Single cell sequencing Research progress Molecular subtyping 分子分型 循环肿瘤细胞 单细胞测序 研究进展 |
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| Notes | Li Jianbin, Jiang Zefei （Department of Breast Cancer, Affiliated Hospital of Academy of Military Medical Sciences, Beifing 100071, China） Although circulating tumor cells（CTCs） have long been identified,it was not until the approval of CellSearch system that CTCs are current lyunder in-depth investigation.The CTCs technology has advanced from simple cell counting into era of molecular subtyping. The development of sequencing technologies and liquid biopsy has made it possible to sequence single cell genomes. In the recent years, how to take advantage of CTCs as a useful tool to clarify the mechanisms of carcinogenesis and cancer development and to predict the patient survival have become a hot issue. 11-2152/R Circulating tumor cells ; Molecular subtyping; Single cell sequencing ;Research progress |
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| PublicationTitle | 中华肿瘤杂志 |
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| PublicationYear | 2016 |
| Publisher | 军事医学科学院附属医院乳腺肿瘤科, 北京,100071 |
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| SubjectTerms | 分子分型 单细胞测序 循环肿瘤细胞 研究进展 |
| Title | 循环肿瘤细胞研究进展：从计数到表型的转变 |
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