循环肿瘤细胞研究进展：从计数到表型的转变

尽管循环肿瘤细胞（CTCs）的发现已有较长时间，但自第一台用于检测CTCs的Cellsearch平台上市之后，CTCs才开始得到重视并深入研究。目前，CTCs已经从单纯的计数走向分子分型时代，随着测序技术的发展和液体活检需求的提高，利用CTCs行单细胞测序已成为可能。如何充分利用CTCs揭示肿瘤的发生与发展，判断患者的生存和预后已经成为关注的热点。...

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Bibliographic Details
Published in中华肿瘤杂志 Vol. 38; no. 12; pp. 881 - 885
Main Author 李健斌 江泽飞
Format Journal Article
LanguageChinese
Published 军事医学科学院附属医院乳腺肿瘤科, 北京,100071 2016
Subjects
分子分型
单细胞测序
循环肿瘤细胞
研究进展
Subject words] Circulating tumor cells
Single cell sequencing
Research progress
Molecular subtyping
分子分型
循环肿瘤细胞
单细胞测序
研究进展
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Summary:尽管循环肿瘤细胞（CTCs）的发现已有较长时间，但自第一台用于检测CTCs的Cellsearch平台上市之后，CTCs才开始得到重视并深入研究。目前，CTCs已经从单纯的计数走向分子分型时代，随着测序技术的发展和液体活检需求的提高，利用CTCs行单细胞测序已成为可能。如何充分利用CTCs揭示肿瘤的发生与发展，判断患者的生存和预后已经成为关注的热点。
Bibliography:Li Jianbin, Jiang Zefei （Department of Breast Cancer, Affiliated Hospital of Academy of Military Medical Sciences, Beifing 100071, China）
Although circulating tumor cells（CTCs） have long been identified,it was not until the approval of CellSearch system that CTCs are current lyunder in-depth investigation.The CTCs technology has advanced from simple cell counting into era of molecular subtyping. The development of sequencing technologies and liquid biopsy has made it possible to sequence single cell genomes. In the recent years, how to take advantage of CTCs as a useful tool to clarify the mechanisms of carcinogenesis and cancer development and to predict the patient survival have become a hot issue.
11-2152/R
Circulating tumor cells ; Molecular subtyping; Single cell sequencing ;Research progress
ISSN:0253-3766
DOI:10.3760/cma.j.issn.0253-3766.2016.12.001