血清钾水平与冠状动脉病变程度的相关性研究

目的：探讨血清钾水平与冠状动脉病变程度的关联性。方法纳入行冠状动脉造影者246例，按病变累及主要冠状动脉支数分为对照组（0只病变，81例）、单支病变组（43例）、双支病变组（46例）和三支病变组（76例），按照血清钾水平分为低水平血清钾组（低钾组，K＋＜4.0 mmol/L）99例和高水平血清钾组（高钾组，K＋≥4.0 mmol/L）147例；采用Gensini评分定量评估各支冠状动脉的狭窄程度；比较各组的临床资料，分析Gensini评分与各临床指标的相关性，采用Logistic回归分析冠心病的危险因素。结果（1）三支病变组的年龄、男性、吸烟、2型糖尿病、高血压患者比例均高于对照组，三支病变组...

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Bibliographic Details
Published in天津医药 Vol. 43; no. 3; pp. 296 - 299
Main Author 牛雪凝 李广平
Format Journal Article
LanguageChinese
Published 天津医科大学第二医院心脏科、天津心脏病学研究所 邮编300211 2015
Subjects
Gensini评分
冠状动脉病变
动脉粥样硬化
危险因素
钾
atherosclerosis
serum potassium
risk factors
危险因素
coronary atherosclerotic lesion
冠状动脉病变
动脉粥样硬化
Gensini评分
Gensini’s score
钾
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Summary:目的：探讨血清钾水平与冠状动脉病变程度的关联性。方法纳入行冠状动脉造影者246例，按病变累及主要冠状动脉支数分为对照组（0只病变，81例）、单支病变组（43例）、双支病变组（46例）和三支病变组（76例），按照血清钾水平分为低水平血清钾组（低钾组，K＋＜4.0 mmol/L）99例和高水平血清钾组（高钾组，K＋≥4.0 mmol/L）147例；采用Gensini评分定量评估各支冠状动脉的狭窄程度；比较各组的临床资料，分析Gensini评分与各临床指标的相关性，采用Logistic回归分析冠心病的危险因素。结果（1）三支病变组的年龄、男性、吸烟、2型糖尿病、高血压患者比例均高于对照组，三支病变组的血清钾浓度低于对照组和单支病变组（mmol/L：3.97±0.37 vs 4.11±0.33 vs 4.13±0.41），差异均有统计学意义；双支病变组的年龄、男性、高血压病患者比例高于对照组。单支病变组的男性和高血压患者比例高于对照组。各组Gensini评分：三支病变组＞双支病变组＞单支病变组＞对照组（均P＜0.05）。（2）低钾组Gensini评分[36（8，94）]高于高钾组[16（0，56）]，差异有统计学意义。（3）血清钾与Gensini评分呈负相关（r=-0.206， P=0.001）。（4）高龄、男性、血清钾低水平、合并有糖尿病和高血压为冠心病的危险因素。结论血清钾水平与冠状动脉病变严重程度呈负相关，血清钾低水平为冠心病的独立危险因素。
Bibliography:Objective To determine the association between serum potassium level and the severity of coronary artery atherosclerosis. Methods A total of 246 patients underwent coronary artery angiography were included into this study, and were divided into four groups according to the involved main coronary artery：control group （0 diseased vessel, n=81）, one dis-eased vessel group （n=43）, double diseased vessel group （n=46） and three diseased vessel group （n=76）. Patients were also di-vided into low potassium group （K＋〈4.0 mmol/L, n=99） and high potassium group （K＋≥4.0 mmol/L, n=147） according to the levels of serum potassium. The severity of coronary stenosis was quantitated by Gensini score system. The clinical data were compared between groups. The relationship between Gensini score system and clinical information was analyzed. The multi-ple regression method was used to analyse the risk factors of coronary heart disease （CHD）. Results （1） There were higher percentages of elders, male, smoking, diabetes mellitus and h
ISSN:0253-9896
DOI:10.3969/j.issn.0253-9896.2015.03.020