Oxidative balance score and oxidative stress biomarkers in a study of Whites, African Americans, and African immigrants

• Published in: Biomarkers Vol. 19; no. 6; pp. 471 - 480
• Main Authors: Lakkur, Sindhu, Bostick, Roberd M., Roblin, Douglas, Ndirangu, Murugi, Okosun, Ike, Annor, Francis, Judd, Suzanne, Dana Flanders, W., Stevens, Victoria L., Goodman, Michael
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.09.2014; Taylor & Francis
• Subjects: Adult; Africa, Western - ethnology; African Americans; beta Carotene - blood; Biomarkers - blood; Carotenoids - blood; Cross-Sectional Studies; Cryptoxanthins - blood; Diet; DNA, Mitochondrial - genetics; European Continental Ancestry Group; Gene Dosage; Humans; Isoprostanes - blood; Middle Aged; Oxidative balance; Oxidative Stress; race; Sensitivity and Specificity; Zeaxanthins - blood; Africa, Western; race; oxidative stress; Oxidative balance
• ISSN: 1354-750X; 1366-5804
• DOI: 10.3109/1354750X.2014.937361

Abstract Context: Oxidative balance score (OBS) is a composite measure of multiple pro- and antioxidant exposures. Objective: To investigate associations of OBS with F2-isoprostanes (FIP), mitochondrial DNA copy number (mtDNA), and fluorescent oxidative products (FOP), and assess inter-relationships among the biomarkers. Methods: In a cross-sectional study, associations of a thirteen-component OBS with biomarker levels were assessed using multivariable regression models. Results: Association of OBS with FIP, but not with FOP, was in the hypothesized direction. The results for mtDNA were unstable and analysis-dependent. The three biomarkers were not inter-correlated. Conclusions: Different biomarkers of oxidative stress may reflect different biological processes.