Patient Blood Management in Liver Transplant-A Concise Review

Transfusion of blood products in orthotopic liver transplantation (OLT) significantly increases post-transplant morbidity and mortality and is associated with reduced graft survival. Based on these results, an active effort to prevent and minimize blood transfusion is required. Patient blood managem...

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Published inBiomedicines Vol. 11; no. 4; p. 1093
Main Authors Pérez-Calatayud, Angel Augusto, Hofmann, Axel, Pérez-Ferrer, Antonio, Escorza-Molina, Carla, Torres-Pérez, Bettina, Zaccarias-Ezzat, Jed Raful, Sanchez-Cedillo, Aczel, Manuel Paez-Zayas, Victor, Carrillo-Esper, Raul, Görlinger, Klaus
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.04.2023
MDPI
Subjects
Acidosis
adult and pediatric liver transplant
Anemia
Anticoagulants
Blood platelets
Blood products
Blood transfusion
Blood transfusions
Clinical outcomes
coagulation
Hepatitis C
Hypertension
Immunological tolerance
Kidneys
Liver
Liver cirrhosis
Liver diseases
Liver transplantation
Liver transplants
Morbidity
Mortality
patient blood management
Patients
Plasma
Proteins
Review
Thrombocytopenia
Thrombosis
Transplantation
viscoelastic testing
Viscoelasticity
United States
patient blood management
viscoelastic testing
coagulation
adult and pediatric liver transplant
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Summary:Transfusion of blood products in orthotopic liver transplantation (OLT) significantly increases post-transplant morbidity and mortality and is associated with reduced graft survival. Based on these results, an active effort to prevent and minimize blood transfusion is required. Patient blood management is a revolutionary approach defined as a patient-centered, systematic, evidence-based approach to improve patient outcomes by managing and preserving a patient's own blood while promoting patient safety and empowerment. This approach is based on three pillars of treatment: (1) detecting and correcting anemia and thrombocytopenia, (2) minimizing iatrogenic blood loss, detecting, and correcting coagulopathy, and (3) harnessing and increasing anemia tolerance. This review emphasizes the importance of the three-pillar nine-field matrix of patient blood management to improve patient outcomes in liver transplant recipients.
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ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11041093