Electrospun tilapia collagen nanofibers accelerating wound healing via inducing keratinocytes proliferation and differentiation

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 143; pp. 415 - 422
• Main Authors: Zhou, Tian, Wang, Nanping, Xue, Yang, Ding, Tingting, Liu, Xin, Mo, Xiumei, Sun, Jiao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2016
• Subjects: amino acids; Animals; Bandages; bioactive properties; biocompatible materials; Biomaterials; biomimetics; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes - cytology; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - immunology; Cell Differentiation - drug effects; Cell Line; Cell Proliferation - drug effects; collagen; Collagen - isolation & purification; Collagen - pharmacology; Collagens; colloids; contact angle; cost effectiveness; Dressing; Electrochemical Techniques; Electrospinning; Electrospun tilapia collagen nanofibers; extracellular matrix; Extracellular Matrix - chemistry; gene expression; Gene Expression Regulation - drug effects; HaCaTs differentiation; Humans; immunoglobulin G; immunoglobulin M; Intermediate Filament Proteins - genetics; Intermediate Filament Proteins - metabolism; keratinocytes; Keratinocytes - cytology; Keratinocytes - drug effects; lymphocytes; medicine; Mice; Mice, Inbred BALB C; Nanofibers; Nanofibers - chemistry; Nanofibers - therapeutic use; Protein Precursors - genetics; Protein Precursors - metabolism; protein-glutamine gamma-glutamyltransferase; Rat model; Rats; Rats, Sprague-Dawley; risk; Skin - drug effects; Skin - injuries; Skin - pathology; Skin wound healing; Sponges; Tensile Strength; thermal stability; Tilapia; Tilapia - metabolism; tissue repair; Transglutaminases - genetics; Transglutaminases - metabolism; Wound healing; Wound Healing - drug effects; HaCaTs differentiation; Rat model; Skin wound healing; Electrospun tilapia collagen nanofibers

[Display omitted] •Collagen sponge from tilapia skin was extracted and proved to not induce obvious immune response.•Biomimetic electrospun tilapia collagen nanofibers with suitable tensile strength and thermal stability were developed.•The adhesion, proliferation and differentiation of HaCaTs were...