Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival

Mesenchymal stem cells (MSCs) are very attractive for regenerative medicine due to their relatively easy derivation and broad range of differentiation capabilities, either naturally or induced through cell engineering. However, efficient methods of delivery to diseased tissues and the long-term surv...

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Bibliographic Details
Published inStem cells international Vol. 2016; no. 2016; pp. 1 - 9
Main Authors Janowski, Miroslaw, Lukomska, Barbara, Walczak, Piotr, Nowakowski, Adam
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2016
John Wiley & Sons, Inc
Wiley
Subjects
Brain research
Cell adhesion & migration
Fluids
Gene expression
Genetic engineering
Medicine
R&D
Research & development
Review
Stem cells
Survival
Transplants & implants
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Summary:Mesenchymal stem cells (MSCs) are very attractive for regenerative medicine due to their relatively easy derivation and broad range of differentiation capabilities, either naturally or induced through cell engineering. However, efficient methods of delivery to diseased tissues and the long-term survival of grafted cells still need improvement. Here, we review genetic engineering approaches designed to enhance the migratory capacities of MSCs, as well as extend their survival after transplantation by the modulation of prosurvival approaches, including prevention of senescence and apoptosis. We highlight some of the latest examples that explore these pivotal points, which have great relevance in cell-based therapies.
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Academic Editor: Paulo Henrique Rosado de Castro
ISSN:1687-966X
1687-9678
DOI:10.1155/2016/4956063