Validation and measurement uncertainty evaluation of the GC-MS method for the direct determination of hexamethylenetetramine from foods
A simple GC-MS method has been developed and validated for the direct determination of hexamethylenetetramine (HMT). The separation of HMT was performed using a MXT-1 column. The calibration curve was linear over the concentration range 0.1-25 μg/mL, with a good correlation coefficient ( r =0.9996)....
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| Published in | Food science and biotechnology Vol. 25; no. 5; pp. 1305 - 1311 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Seoul
The Korean Society of Food Science and Technology
01.10.2016
Springer Nature B.V 한국식품과학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-7708 2092-6456 2092-6456 |
| DOI | 10.1007/s10068-016-0205-5 |
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| Abstract | A simple GC-MS method has been developed and validated for the direct determination of hexamethylenetetramine (HMT). The separation of HMT was performed using a MXT-1 column. The calibration curve was linear over the concentration range 0.1-25 μg/mL, with a good correlation coefficient (
r
=0.9996). The recoveries of HMT from foods spiked at 1, 5, and 10 μg/g ranged from 91.7% to 115.2%. Intra-day (
n
=5) and inter-day (
n
=5) precision were less than 7%. The limit of detection and the limit of quantification of the method were 0.05 and 0.15 μg/mL, respectively. The uncertainties associated with food matrix and calibration contributed most to the overall expanded uncertainty. The method validation data indicated that quantitative method could be applied to the direct determination of non-hydrolyzed HMT in foods. |
|---|---|
| AbstractList | A simple GC-MS method has been developed and validated for the direct determination of hexamethylenetetramine (HMT). The separation of HMT was performed using a MXT-1 column. The calibration curve was linear over the concentration range 0.1-25 μg/mL, with a good correlation coefficient (r =0.9996). The recoveries of HMT from foods spiked at 1, 5, and 10 μg/g ranged from 91.7% to 115.2%. Intra-day (n=5) and inter-day (n=5) precision were less than 7%. The limit of detection and the limit of quantification of the method were 0.05 and 0.15 μg/mL, respectively. The uncertainties associated with food matrix and calibration contributed most to the overall expanded uncertainty. The method validation data indicated that quantitative method could be applied to the direct determination of non-hydrolyzed HMT in foods.A simple GC-MS method has been developed and validated for the direct determination of hexamethylenetetramine (HMT). The separation of HMT was performed using a MXT-1 column. The calibration curve was linear over the concentration range 0.1-25 μg/mL, with a good correlation coefficient (r =0.9996). The recoveries of HMT from foods spiked at 1, 5, and 10 μg/g ranged from 91.7% to 115.2%. Intra-day (n=5) and inter-day (n=5) precision were less than 7%. The limit of detection and the limit of quantification of the method were 0.05 and 0.15 μg/mL, respectively. The uncertainties associated with food matrix and calibration contributed most to the overall expanded uncertainty. The method validation data indicated that quantitative method could be applied to the direct determination of non-hydrolyzed HMT in foods. A simple GC-MS method has been developed and validated for the direct determination of hexamethylenetetramine (HMT). The separation of HMT was performed using a MXT-1 column. The calibration curve was linear over the concentration range 0.1-25 μg/mL, with a good correlation coefficient (r =0.9996). The recoveries of HMT from foods spiked at 1, 5, and 10 μg/g ranged from 91.7% to 115.2%. Intra-day (n=5) and inter-day (n=5) precision were less than 7%. The limit of detection and the limit of quantification of the method were 0.05 and 0.15 μg/mL, respectively. The uncertainties associated with food matrix and calibration contributed most to the overall expanded uncertainty. The method validation data indicated that quantitative method could be applied to the direct determination of non-hydrolyzed HMT in foods. A simple GC-MS method has been developed and validated for the direct determination of hexamethylenetetramine (HMT). The separation of HMT was performed using a MXT-1 column. The calibration curve was linear over the concentration range 0.1-25 μg/mL, with a good correlation coefficient ( r =0.9996). The recoveries of HMT from foods spiked at 1, 5, and 10 μg/g ranged from 91.7% to 115.2%. Intra-day ( n =5) and inter-day ( n =5) precision were less than 7%. The limit of detection and the limit of quantification of the method were 0.05 and 0.15 μg/mL, respectively. The uncertainties associated with food matrix and calibration contributed most to the overall expanded uncertainty. The method validation data indicated that quantitative method could be applied to the direct determination of non-hydrolyzed HMT in foods. A simple GC-MS method has been developed and validated for the direct determination of hexamethylenetetramine (HMT). The separation of HMT was performed using a MXT-1 column. The calibration curve was linear over the concentration range 0.1-25 mu g/mL, with a good correlation coefficient (r =0.9996). The recoveries of HMT from foods spiked at 1, 5, and 10 mu g/g ranged from 91.7% to 115.2%. Intra-day (n=5) and inter-day (n=5) precision were less than 7%. The limit of detection and the limit of quantification of the method were 0.05 and 0.15 mu g/mL, respectively. The uncertainties associated with food matrix and calibration contributed most to the overall expanded uncertainty. The method validation data indicated that quantitative method could be applied to the direct determination of non-hydrolyzed HMT in foods. A simple GC-MS method has been developed and validated for the direct determination of hexamethylenetetramine (HMT). The separation of HMT was performed using a MXT-1 column. The calibration curve was linear over the concentration range 0.1-25 μg/mL, with a good correlation coefficient ( =0.9996). The recoveries of HMT from foods spiked at 1, 5, and 10 μg/g ranged from 91.7% to 115.2%. Intra-day ( =5) and inter-day ( =5) precision were less than 7%. The limit of detection and the limit of quantification of the method were 0.05 and 0.15 μg/mL, respectively. The uncertainties associated with food matrix and calibration contributed most to the overall expanded uncertainty. The method validation data indicated that quantitative method could be applied to the direct determination of non-hydrolyzed HMT in foods. A simple GC-MS method has been developed and validated for the direct determination of hexamethylenetetramine (HMT). The separation of HMT was performed using a MXT-1 column. The calibration curve was linear over the concentration range 0.1-25 μg/mL, with a good correlation coefficient (r =0.9996). The recoveries of HMT from foods spiked at 1, 5, and 10 μg/g ranged from 91.7% to 115.2%. Intra-day (n=5) and inter-day (n=5) precision were less than 7%. The limit of detection and the limit of quantification of the method were 0.05 and 0.15 μg/mL, respectively. The uncertainties associated with food matrix and calibration contributed most to the overall expanded uncertainty. The method validation data indicated that quantitative method could be applied to the direct determination of non-hydrolyzed HMT in foods. KCI Citation Count: 5 |
| Author | Kim, Meehye Lim, Ho Soo Kim, Jung Im Hwang, Ju Young Choi, Jae Chon |
| Author_xml | – sequence: 1 givenname: Ho Soo surname: Lim fullname: Lim, Ho Soo email: hslim70@korea.kr organization: Food Additives and Packaging Division, Ministry of Food and Drug Safety – sequence: 2 givenname: Ju Young surname: Hwang fullname: Hwang, Ju Young organization: Food Additives and Packaging Division, Ministry of Food and Drug Safety – sequence: 3 givenname: Jung Im surname: Kim fullname: Kim, Jung Im organization: Food Additives and Packaging Division, Ministry of Food and Drug Safety – sequence: 4 givenname: Jae Chon surname: Choi fullname: Choi, Jae Chon organization: Food Additives and Packaging Division, Ministry of Food and Drug Safety – sequence: 5 givenname: Meehye surname: Kim fullname: Kim, Meehye organization: Food Additives and Packaging Division, Ministry of Food and Drug Safety |
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| CitedBy_id | crossref_primary_10_1007_s10068_022_01108_w crossref_primary_10_1155_2023_5554877 crossref_primary_10_1002_jssc_201800967 crossref_primary_10_1016_j_forc_2017_11_002 crossref_primary_10_1016_j_envres_2024_118894 crossref_primary_10_1039_C7RA07634G |
| Cites_doi | 10.1080/19440049.2014.942706 10.1086/324575 10.2116/analsci.1.381 10.1246/bcsj.41.813 10.1111/j.1365-2621.1989.tb04656.x 10.1016/j.jpba.2005.09.017 10.1016/S1044-0305(99)00047-1 10.1002/jps.2600750422 10.1016/j.jasms.2008.05.001 |
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| References | CR2 Restani, Corsini, Galli (CR1) 1989; 54 Koga, Shinohara, Akiyama (CR11) 1985; 1 CR4 CR3 CR6 CR5 CR8 CR7 CR18 Iwakami, Takzono (CR20) 1968; 41 CR16 CR15 CR14 CR13 Strom, Jun (CR19) 1986; 75 Cottin, Szopa, Moore (CR12) 2001; 561 Stein (CR17) 1999; 10 Pavitrapok, Williams (CR10) 2006; 40 Lim, Kim, Ko, Kim (CR9) 2014; 31 P Restani (205_CR1) 1989; 54 JG Strom (205_CR19) 1986; 75 205_CR6 205_CR13 205_CR5 205_CR4 205_CR15 205_CR3 205_CR14 205_CR2 C Pavitrapok (205_CR10) 2006; 40 H Cottin (205_CR12) 2001; 561 205_CR16 205_CR18 205_CR8 205_CR7 SE Stein (205_CR17) 1999; 10 M Koga (205_CR11) 1985; 1 Y Iwakami (205_CR20) 1968; 41 HS Lim (205_CR9) 2014; 31 |
| References_xml | – ident: CR18 – volume: 31 start-page: 1489 year: 2014 end-page: 1495 ident: CR9 article-title: Determination of hexamethylenetetramine in foods by high-performance liquid chromatography (HPLC) publication-title: Food Addit. Contam. A doi: 10.1080/19440049.2014.942706 – volume: 561 start-page: 139 year: 2001 end-page: 142 ident: CR12 article-title: Production of hexamethylenetetramine in photolyzed and irradiated interstellar cometary ice analogs publication-title: Astrophys. J. doi: 10.1086/324575 – ident: CR3 – ident: CR4 – ident: CR14 – ident: CR15 – ident: CR2 – ident: CR16 – volume: 1 start-page: 381 year: 1985 end-page: 384 ident: CR11 article-title: Gas chromatographic determination of trace amounts of hexamethylenetetramine in water using an iodine charge-transfer complex publication-title: Anal. Sci. doi: 10.2116/analsci.1.381 – ident: CR13 – volume: 41 start-page: 813 year: 1968 end-page: 817 ident: CR20 article-title: Thermal decomposition of hexamethylene tetramine publication-title: B. Chem. Soc. Jpn. doi: 10.1246/bcsj.41.813 – ident: CR6 – volume: 54 start-page: 578 year: 1989 end-page: 580 ident: CR1 article-title: A novel approach to quantify the amount of formaldehyde added to milk in grana padano cheese production publication-title: J. Food Sci. doi: 10.1111/j.1365-2621.1989.tb04656.x – ident: CR5 – ident: CR7 – ident: CR8 – volume: 40 start-page: 1243 year: 2006 end-page: 1248 ident: CR10 article-title: Determination of methenamine, methenamine mandelate and methenamine hippurate in pharmaceutical preparations using ion-exchange HPLC publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2005.09.017 – volume: 10 start-page: 770 year: 1999 end-page: 781 ident: CR17 article-title: An integrated method for spectrum extraction and compound identification from gas chromatography/mass spectrometry data publication-title: J. Am. Soc. Mass Spectr. doi: 10.1016/S1044-0305(99)00047-1 – volume: 75 start-page: 416 year: 1986 end-page: 420 ident: CR19 article-title: Separation and quantitation of methenamine in urine by ion-pair extraction publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600750422 – volume: 10 start-page: 770 year: 1999 ident: 205_CR17 publication-title: J. Am. Soc. Mass Spectr. doi: 10.1016/S1044-0305(99)00047-1 – volume: 75 start-page: 416 year: 1986 ident: 205_CR19 publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600750422 – ident: 205_CR5 – ident: 205_CR8 – ident: 205_CR6 – ident: 205_CR7 – ident: 205_CR3 – ident: 205_CR4 – ident: 205_CR2 – volume: 40 start-page: 1243 year: 2006 ident: 205_CR10 publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2005.09.017 – volume: 54 start-page: 578 year: 1989 ident: 205_CR1 publication-title: J. Food Sci. doi: 10.1111/j.1365-2621.1989.tb04656.x – volume: 561 start-page: 139 year: 2001 ident: 205_CR12 publication-title: Astrophys. J. doi: 10.1086/324575 – ident: 205_CR18 doi: 10.1016/j.jasms.2008.05.001 – ident: 205_CR13 – volume: 41 start-page: 813 year: 1968 ident: 205_CR20 publication-title: B. Chem. Soc. Jpn. doi: 10.1246/bcsj.41.813 – volume: 31 start-page: 1489 year: 2014 ident: 205_CR9 publication-title: Food Addit. Contam. A doi: 10.1080/19440049.2014.942706 – volume: 1 start-page: 381 year: 1985 ident: 205_CR11 publication-title: Anal. Sci. doi: 10.2116/analsci.1.381 – ident: 205_CR14 – ident: 205_CR15 – ident: 205_CR16 |
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| SubjectTerms | Calibration Chemistry Chemistry and Materials Science correlation Correlation coefficient Correlation coefficients detection limit Food Food matrix Food Science foods gas chromatography-mass spectrometry Hexamethylenetetramine Nutrition quantitative analysis Uncertainty 식품과학 |
| Title | Validation and measurement uncertainty evaluation of the GC-MS method for the direct determination of hexamethylenetetramine from foods |
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