Association of polymorphic markers of genes FTO , KCNJ11, CDKAL1, SLC30A8, and CDKN2B with type 2 diabetes mellitus in the Russian population

• Published in: PeerJ (San Francisco, CA) Vol. 5; p. e3414
• Main Authors: Nikitin, Aleksey G, Potapov, Viktor Y, Brovkina, Olga I, Koksharova, Ekaterina O, Khodyrev, Dmitry S, Philippov, Yury I, Michurova, Marina S, Shamkhalova, Minara S, Vikulova, Olga K, Smetanina, Svetlana A, Suplotova, Lyudmila A, Kononenko, Irina V, Kalashnikov, Viktor Y, Smirnova, Olga M, Mayorov, Alexander Y, Nosikov, Valery V, Averyanov, Alexander V, Shestakova, Marina V
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 13.07.2017; PeerJ, Inc; PeerJ Inc
• Subjects: Adipocytes; Age; Analysis; Biological markers; CDKN2B gene; Cell cycle; Cell growth; Demographic aspects; Diabetes; Diabetes and Endocrinology; Diabetes mellitus; Endocrinology; Fto gene; Gene expression; Genetic aspects; Genetic predisposition; Genetics; Genomes; Glucose; Glucose metabolism; Hyperglycemia; Insulin; Insulin resistance; KCNJ11 gene; Kinases; Medical research; Mutation; Obesity; Pancreas; Physiology; Polymorphic marker; Polymorphism; Population; Population studies; Proteins; Secretion; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Statistical analysis; Studies; Type 2 diabetes; Type 2 diabetes mellitus; Russia; Genetic predisposition; Polymorphic marker; Type 2 diabetes mellitus
• ISSN: 2167-8359; 2167-8359
• DOI: 10.7717/peerj.3414

The association of type 2 diabetes mellitus (T2DM) with the and genes in the Russian population has not been well studied. In this study, we analysed the population frequencies of polymorphic markers of these genes. The study included 862 patients with T2DM and 443 control subjects of Russian origin. All subjects were genotyped for 10 single nucleotide polymorphisms (SNPs) of the genes using real-time PCR (TaqMan assays). HOMA-IR and HOMA- were used to measure insulin resistance and -cell secretory function, respectively. The analysis of the frequency distribution of polymorphic markers for genes and showed statistically significant associations with T2DM in the Russian population. The association between the gene and T2DM was not statistically significant. The polymorphic markers of the gene, of the gene, of the gene and , and of the gene showed a significant association with impaired glucose metabolism or impaired -cell function. In the Russian population, genes, which affect insulin synthesis and secretion in the -cells of the pancreas, play a central role in the development of T2DM.