Adherens Junction and E-Cadherin complex regulation by epithelial polarity

E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial sheets. Through the homophilic association of E-Cadherin molecules expressed on neighboring cells, they ensure intercellular adhesion amongst epithelial cells, and regulate many key aspects of epithelial biology. Whil...

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Bibliographic Details
Published inCellular and molecular life sciences : CMLS Vol. 73; no. 18; pp. 3535 - 3553
Main Authors Coopman, Peter, Djiane, Alexandre
Format Journal Article Book Review
LanguageEnglish
Published Cham Springer International Publishing 01.09.2016
Springer Nature B.V
Subjects
Adherens Junctions - metabolism
Animals
Apoptosis
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cadherins - chemistry
Cadherins - metabolism
Catenins - chemistry
Catenins - metabolism
Cell adhesion & migration
Cell Biology
Cell Polarity
Environmental changes
Epithelial Cells - cytology
Epithelial Cells - metabolism
Life Sciences
Membrane Proteins - metabolism
Molecular biology
Phosphoric Monoester Hydrolases - metabolism
Phosphorylation
Review
src-Family Kinases - metabolism
Adherens Junctions
Remodeling
Magi scaffolds
Epithelial polarity
E-Cadherin
Par3
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Summary:E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial sheets. Through the homophilic association of E-Cadherin molecules expressed on neighboring cells, they ensure intercellular adhesion amongst epithelial cells, and regulate many key aspects of epithelial biology. While their adhesive role requires these structures to remain stable, AJs are also extremely plastic. This plasticity allows for the adaptation of the cell to its changing environment: changes in neighbors after cell division, cell death, or cell movement, and changes in cell shape during differentiation. In this review we focus on the recent advances highlighting the critical role of the apico-basal polarity machinery, and in particular of the Par3/Bazooka scaffold, in the regulation and remodeling of AJs. We propose that by regulating key phosphorylation events on the core E-Cadherin complex components, Par3 and epithelial polarity promote meta-stable protein complexes governing the correct formation, localization, and functioning of AJ.
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ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-016-2260-8