Angiogenesis and vasculogenesis: Inducing the growth of new blood vessels and wound healing by stimulation of bone marrow–derived progenitor cell mobilization and homing

During embryonic development, the vasculature is among the first organs to form and is in charge of maintaining metabolic homeostasis by supplying oxygen and nutrients and removing waste products. As one would expect, blood vessels are critical not only for organ growth in the embryo but also for re...

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Published inJournal of vascular surgery Vol. 45; no. 6; pp. A39 - A47
Main Author Velazquez, Omaida C., MD
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 01.06.2007
Subjects
Animals
Blood Vessels - metabolism
Blood Vessels - physiopathology
Bone Marrow Cells - metabolism
Cell Differentiation
Cell Lineage
Cell Movement
Cytokines - metabolism
Diabetes Complications - metabolism
Diabetes Complications - physiopathology
Diabetes Complications - therapy
Disease Models, Animal
Humans
Hyperbaric Oxygenation
Hyperoxia - metabolism
Hyperoxia - physiopathology
Ischemia - metabolism
Ischemia - physiopathology
Ischemia - therapy
Mice
Neovascularization, Physiologic
Signal Transduction
Stem Cells - metabolism
Surgery
Wound Healing
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Summary:During embryonic development, the vasculature is among the first organs to form and is in charge of maintaining metabolic homeostasis by supplying oxygen and nutrients and removing waste products. As one would expect, blood vessels are critical not only for organ growth in the embryo but also for repair of wounded tissue in the adult. An imbalance in angiogenesis (a time-honored term that globally refers to the growth of new blood vessels) contributes to the pathogenesis of numerous malignant, inflammatory, ischemic, infectious, immune, and wound-healing disorders. This review focuses on the central role of the growth of new blood vessels in ischemic and diabetic wound healing and defines the most current nomenclature that describes the neovascularization process in wounds. There are now two well-defined, distinct, yet interrelated processes for the formation of postnatal new blood vessels, angiogenesis, and vasculogenesis. Reviewed are recent new data on vasculogenesis that promise to advance the field of wound healing.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0741-5214
1097-6809
DOI:10.1016/j.jvs.2007.02.068