Timing of Last Preoperative Dose of Infliximab Does Not Increase Postoperative Complications in Inflammatory Bowel Disease Patients

• Published in: Digestive diseases and sciences Vol. 61; no. 9; pp. 2602 - 2607
• Main Authors: Alsaleh, Anas, Gaidos, Jill K. J., Kang, Le, Kuemmerle, John F.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2016; Springer; Springer Nature B.V
• Subjects: Abdominal Abscess - epidemiology; Adolescent; Adult; Analysis; Anastomotic Leak - epidemiology; Biochemistry; Care and treatment; Child; Colitis, Ulcerative - therapy; Complications; Complications and side effects; Crohn Disease - therapy; Digestive System Surgical Procedures - methods; Female; Gastroenterology; Gastrointestinal Agents - administration & dosage; Hepatology; Humans; Ileus - epidemiology; Inflammatory bowel disease; Inflammatory Bowel Diseases - therapy; Infliximab; Infliximab - administration & dosage; Intestinal Obstruction - epidemiology; Male; Medical societies; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Article; Postoperative Complications - epidemiology; Preoperative Care - methods; Reoperation - statistics & numerical data; Retrospective Studies; Risk Factors; Surgery; Surgical Wound Infection - epidemiology; Time Factors; Transplant Surgery; Ulcerative colitis; Venous Thromboembolism - epidemiology; Young Adult; Infliximab; Postoperative complications; Ulcerative colitis; Crohn’s disease
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-016-4171-9

Background The association between preoperative use of infliximab and postoperative complications in patients with inflammatory bowel disease (IBD) is a subject of continued debate. Results from studies examining an association between the timing of last preoperative dose of infliximab and postoperative complications remain inconsistent. Aims To assess whether timing of last dose of infliximab prior to surgery affects the rate of postoperative complications in patients with Crohn’s disease or ulcerative colitis. Methods Retrospective chart review of IBD patients who have undergone surgery while receiving therapy with infliximab was conducted. Forty-seven patients were included in the analysis. Results No significant association was found between timing of infliximab and the rate of postoperative complications. Age, gender, disease type, steroid use, preoperative status, surgery type, or surgeon type was not associated with increased rate of postoperative complications. Conclusion Timing of last dose of infliximab does not affect the rate of postoperative complications in patients with Crohn’s disease or ulcerative colitis.