A dose-response study of arsenic exposure and markers of oxidative damage in Bangladesh

• Published in: Journal of occupational and environmental medicine Vol. 56; no. 6; p. 652
• Main Authors: Harper, Kristin N, Liu, Xinhua, Hall, Megan N, Ilievski, Vesna, Oka, Julie, Calancie, Larissa, Slavkovich, Vesna, Levy, Diane, Siddique, Abu, Alam, Shafiul, Mey, Jacob L, van Geen, Alexander, Graziano, Joseph H, Gamble, Mary V
• Format: Journal Article
• Language: English
• Published: United States 01.06.2014
• Subjects: 8-Hydroxy-2'-Deoxyguanosine; Adult; Arsenic - adverse effects; Arsenic - metabolism; Bangladesh; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - analysis; Dose-Response Relationship, Drug; Environmental Exposure - adverse effects; Female; Humans; Male; Middle Aged; Oxidative Stress - physiology; Protein Carbonylation; Water Pollution, Chemical; Bangladesh
• ISSN: 1536-5948
• DOI: 10.1097/JOM.0000000000000166

To evaluate the dose-response relationship between arsenic (As) exposure and markers of oxidative damage in Bangladeshi adults. We recruited 378 participants drinking water from wells assigned to five water As exposure categories; the distribution of subjects was as follows: (1) less than 10 μg/L (n=76); (2) 10 to 100 μg/L (n=104); (3) 101 to 200 μg/L (n=86); (4) 201 to 300 μg/L (n=67); and (5) more than 300 μg/L (n=45). Arsenic concentrations were measured in well water, as well as in urine and blood. Urinary 8-oxo-2'-deoxyguanosine and plasma protein carbonyls were measured to assess oxidative damage. None of our measures of As exposure were significantly associated with protein carbonyl or 8-oxo-2'-deoxyguanosine levels. We found no evidence to support a significant relationship between long-term exposure to As-contaminated drinking water and biomarkers of oxidative damage among Bangladeshi adults.