RF9 Powerfully Stimulates Gonadotrophin Secretion in the Ewe: Evidence for a Seasonal Threshold of Sensitivity

• Published in: Journal of neuroendocrinology Vol. 24; no. 5; pp. 725 - 736
• Main Authors: Caraty, A., Blomenröhr, M., Vogel, G. M. T., Lomet, D., Briant, C., Beltramo, M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2012; Blackwell; Wiley
• Subjects: Adamantane - administration & dosage; Adamantane - analogs & derivatives; Adamantane - pharmacokinetics; Adamantane - pharmacology; Animals; Biological and medical sciences; Blood-brain barrier; Central Nervous System - drug effects; Central Nervous System - metabolism; Cerebrospinal fluid; Data processing; Dipeptides - administration & dosage; Dipeptides - pharmacokinetics; Dipeptides - pharmacology; Dose-Response Relationship, Drug; Drug Resistance - drug effects; Drug Resistance - physiology; Female; Fundamental and applied biological sciences. Psychology; GnRH; Gonadotropin-releasing hormone; Gonadotropins - secretion; GPR147; Half-Life; Hormones; Hypothalamus; Injections, Intravenous; Injections, Intraventricular; Life Sciences; Luteinizing hormone; Luteinizing Hormone - secretion; Neurons and Cognition; Peripheral blood; Pharmacokinetics; Pituitary; Pituitary (anterior); Receptors, Neuropeptide - antagonists & inhibitors; Reproduction; Reproduction - drug effects; Reproduction - physiology; RF9; RFRP3; Seasons; Secretion; Sheep; Up-Regulation - drug effects; Vertebrates: endocrinology; RF9; Secretion; RFRP3; Gonadotropin RH; Hypothalamic hormone; Vertebrata; Ewe; Sensitivity; Mammalia; Adenohypophyseal hormone; Animal; Luteinizing hormone; Sheep; Artiodactyla; Hormone releasing factor; GnRH; LH; Ungulata; GPR147; rf9; rfrp3; gpr147; anoestrus; lh; gnrh; sheep

GPR147 and its endogenous ligands, RFRPs, are emerging as important actors in hypothalamic‐pituitary axis control. The role of this system would be to inhibit gonadotrophin secretion. However, data on the subject are contradictory. The discovery of RF9 (adamantanecarbonyl‐RF‐2‐NH2), a GPR147 antagon...