Blonanserin in the treatment of delirium

• Published in: Psychiatry and clinical neurosciences Vol. 65; no. 4; pp. 389 - 391
• Main Authors: Kato, Koji, Yamada, Keigo, Maehara, Mizuki, Akama, Fumiaki, Kimoto, Keitaro, Saito, Mai, Yano, Hiroshi, Ichimura, Atsushi, Matsumoto, Hideo
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.06.2011; Wiley-Blackwell
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Aged, 80 and over; Antipsychotic Agents - therapeutic use; atypical antipsychotics; Biological and medical sciences; blonanserin; Data processing; delirium; Delirium - drug therapy; Dopamine Antagonists - therapeutic use; Female; Humans; intensive care unit; Intensive care units; Male; Medical sciences; Middle Aged; Neuropharmacology; Organic mental disorders. Neuropsychology; Pharmacology. Drug treatments; Piperazines - therapeutic use; Piperidines - therapeutic use; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Retrospective Studies; Serotonin Antagonists - therapeutic use; Side effects; treatment; Treatment Outcome; Delirium; Atypical antipsychotic; Treatment; Neuroleptic; Psychotropic; Blonanserin; atypical antipsychotics; Mental confusion; Intensive care unit; Organic mental disorder
• ISSN: 1323-1316; 1440-1819
• DOI: 10.1111/j.1440-1819.2011.02213.x

The purpose of the present study was to provide preliminary data on the usefulness and safety of blonanserin for patients with delirium in the intensive care unit (ICU). The charts of 32 consecutive patients with delirium in the ICU were retrospectively reviewed. These patients were treated with blonanserin. A total of 96.6% had reduction in Memorial Delirium Assessment Scale score. The proportion of patients with side‐effects was 24.1%. Blonanserin may be effective and safe in the treatment of delirium in the ICU.