The Role of Pro‐Inflammatory Cytokines in Inflammatory Bowel Disease Growth Retardation

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 43; no. 2; pp. 144 - 155
• Main Authors: Wong, S.C., MacRae, V.E., McGrogan, P., Ahmed, S.F.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins, Inc 01.08.2006; Lippincott
• Subjects: Adolescent; Biological and medical sciences; Body Height - drug effects; Body Height - physiology; Body Weight - drug effects; Body Weight - physiology; Child; Child, Preschool; Crohn disease; Cytokines - adverse effects; Cytokines - biosynthesis; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Growth - drug effects; Growth - physiology; Growth Disorders - drug therapy; Growth Disorders - etiology; Growth hormone; Growth Hormone - therapeutic use; Humans; Inflammatory Bowel Diseases - metabolism; Inflammatory Bowel Diseases - physiopathology; Male; Management; Medical sciences; Other diseases. Semiology; Puberty; Puberty, Delayed - etiology; Stature; Steroids; Steroids - therapeutic use; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Ulcerative colitis; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Crohn disease; Stature-Puberty-Growth hormone-Steroids-Management-Crohn disease-Ulcerative colitis; Steroid hormone; Cytokine; Gastroenterology; Somatotropin hormone; Digestive diseases; Intestinal disease; Metabolic diseases; Growth retardation; Inflammatory disease; Ulcerative colitis
• ISSN: 0277-2116; 1536-4801
• DOI: 10.1097/01.mpg.0000226374.18494.14

ABSTRACT Childhood inflammatory bowel disease (IBD) especially those with Crohn disease is commonly complicated by faltering growth and pubertal delay. Pro‐inflammatory cytokines are often elevated in IBD and may affect linear growth and puberty either systemically or at the level of the growth plate. Further study of the underlying mechanisms of the deleterious effects of cytokines on the growth plate may improve management of faltering growth in childhood IBD. Well‐controlled clinical studies of the respective effect of nutritional support, immunomodulatory therapy, biological agents and growth and puberty promoting agents on managing faltering growth also require further attention.