长链非编码RNA与乳腺癌侵袭转移相关性研究进展

长链非编码RNA（lnc RNA）是一类长度大于200 nt,不具备编码蛋白质能力的功能性RNA分子。研究发现,lnc RNA的异常表达与乳腺癌的进展关系密切,部分lnc RNA参与调控乳腺癌侵袭转移的过程。本文对乳腺癌中异常表达的lnc RNA及其与乳腺癌侵袭转移的相关性进行综述,以期为乳腺癌的诊疗提供新的思路。...

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Bibliographic Details
Published in:天津医药 Vol. 43; no. 5; pp. 566 - 569
Main Author: 苏薇 张瑾
Format: Journal Article
Language:Chinese
Published: 天津市肿瘤防治重点实验室 2015
乳腺癌防治教育部重点实验室
天津医科大学肿瘤医院乳腺肿瘤三科 300060
天津市乳腺癌防治研究中心
国家肿瘤临床医学研究中心
Subjects:
乳腺癌
分子标志物
综述
肿瘤侵润
肿瘤转移
长链非编码RNA
乳腺癌
lncRNA
长链非编码RNA
neoplasm invasiveness
review
肿瘤转移
molecular marker
neoplasm metastasis
breast cancer
综述
肿瘤侵润
分子标志物
Online Access:Get full text
ISSN:0253-9896
DOI:10.11958/j.issn.0253-9896.2015.05.030
More Information
Summary:长链非编码RNA（lnc RNA）是一类长度大于200 nt,不具备编码蛋白质能力的功能性RNA分子。研究发现,lnc RNA的异常表达与乳腺癌的进展关系密切,部分lnc RNA参与调控乳腺癌侵袭转移的过程。本文对乳腺癌中异常表达的lnc RNA及其与乳腺癌侵袭转移的相关性进行综述,以期为乳腺癌的诊疗提供新的思路。
Bibliography:Long non-coding RNA（lncRNA） is a group of functional RNA molecules, which is more than 200 nucleotides in length and lacks ability of encoding protein. The current study indicates that the abnormal expression of lncRNA is closely related with breast cancer progression. Some lncRNA takes part in regulating the process of breast cancer invasion and me- tastasis. This article reviews the abnormal expression of lncRNA in breast cancer and the relevance with breast cancer invasion and metastasis, which is expected to provide new strategy for breast cancer diagnosis and treatment.
lneRNA; breast cancer; neoplasm invasiveness; neoplasm metastasis; molecular marker; review
SU Wei, ZHANG Jin （The 3rd Department of Breast Cancer Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center of Cancer, Tianjin 300060, China; Tianjin Breast Cancer Prevention, Treatment and Research Center; Key laboratory of breast cancer prevention and therapy,＂ Key Laboratory of Breast Cancer Prevention and Th
ISSN:0253-9896
DOI:10.11958/j.issn.0253-9896.2015.05.030